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diagnosis hematology causes algorithm oncology classification disorders hemolytic pathophysiology rheumatology thrombocytosis acidosis approach arthritis atlas bandemia bleeding bruising calculation cancer
Red Blood Cell (RBC) Morphology Atlas • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
, Liver diseases ... - Sickle cell anemia ... Malignant tumors, Acute ... key #diagnosis #differential ... #hematology
Hepatobiliary Manifestations of Sickle Cell Disease Acute sickle cell hepatic crisis: • Fever, acute onset RUQ pain,
Disease Acute ... Supportive with treatment ... hepatomegaly and anemia ... Hepatobiliary #hepatology ... #hepatitis #differential
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... - Differential ... Algorithm • Sickle cells ... Consider sickle cell ... Diagnosis #Algorithm #workup
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
can indicate disease ... • Neutropenia, anemia ... microglobulin Treatment ... ’s lymphoma or acute ... Leukemia #diagnosis #workup
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
usually IgG) (e.g. lupus ... Hemoglobinopathies (e.g. sickle cell ... Extravascular #Causes #differential ... #diagnosis #hematology ... #anemia
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
Platelet Count - Differential ... for workup, including ... hemolysis, deficiency anemia ... Rebound effect from treatment ... Vasculitides, IBD, Celiac disease
Eosinophil Disorders Testing Algorithm INDICATIONS FOR TESTING: • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
during medical evaluation ... /µL Workup • Screen ... glucocorticoid treatment ... Disorders #Algorithm #Differential ... #diagnosis #hematology
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Thrombocytosis - Differential ... Infectious: • Acute ... disorders • Celiac disease ... effect following treatment ... Iron deficiency anemia
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... Myeloproliferative Disease ... Workup: • Complete ... blood count with differential ... Syndromes #diagnosis #hematology
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
Chronic kidney disease ... Index > 3: • Acute ... defects (e.g. sickle cell ... Production #Index #hematology ... #anemia #differential
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