11 results
Myositis and Myopathies
Polymyositis 
 • Progressive, symmetric muscle weakness 
 • Elevated CK, +Anti-Jo, +Anti-Mi2
Dermatomyositis
Anti-retrovirals, Gemcitabine Lupus ... joint aches • +ANA ... uncommon 5-15% of lupus ... differential #diagnosis #comparison ... #rheumatology
I’M DAMN SHARP - Lupus Diagnosis Mnemonic
I  	 Immunoglobulins (Anti-dsDNA, Anti-Sm, Anti-phospholipid)
M 	 Malar Rash
D
M DAMN SHARP - Lupus ... Antinuclear Antibody (ANA ... ) M Mucositis ( ... sle #systemic #lupus ... erythematosus #rheumatology
Autoantibodies in Rheumatology
 • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
Autoantibodies in Rheumatology ... • Lupus (SLE): ... ANA (anti-nuclear ... glycoprotein I (ß2GP), Lupus ... Peptide (CCP) • Myositis
Antinuclear Antibodies (ANA)
ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
, Drug-induced Lupus ... Speckled: Systemic lupus ... Sjögren Syndrome, Myositis ... , Drug-Induced Lupus ... #patterns #rheumatology
Systemic Lupus Erythematosus - Diagnosis
Manifestations:
 - Arthritis 69%
 - Malar rash 40%
 - Fever 36%
 -
Systemic Lupus Erythematosus ... anemia 4% - Myositis ... Auto-Antibodies: - ANA ... Diagnosis and Lupus ... #differential #rheumatology
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
Workup: - ANA ... cutaneous-DIL • Evolution ... Workup: - ANA ... #sle #comparison ... #table #rheumatology
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary
 • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... , oral ulcers, Lupus ... Workup: - ANA ... management of SLE • Evolution ... Management #Summary #rheumatology
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
laboratory findings (ANA ... Non-autoimmune rheumatologic ... • Transverse Myelitis ... antibodies • (-) ANA ... Erythematosus #Diagnosis #Rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
< 30 years - Aorta ... branches • GCA: - Aorta ... such as systemic lupus ... LFT • ESR • ANA ... differential #diagnosis #rheumatology
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases

• Septic arthritis - Gram stain and culture of
Rheumatology Workup ... joint • Systemic lupus ... thus, a negative ANA ... level to exclude myositis ... diagnosis #testing #Rheumatology