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diagnosis management erythematosus differential systemic classification druginduced activation autoantibodies causes comparison dil disorders eularacr macrophage mas mimickers platelet polychondritis relapsing
SLICC SLE Diagnostic Criteria - Systemic Lupus Erythematosus Clinical and Immunologic Criteria CLINICAL CRITERIA - ACUTE CUTANEOUS LUPUS
SLICC SLE Diagnostic ... (<1000/MM3) - THROMBOCYTOPENIA ... - ANA level above ... #Diagnosis #Rheumatology ... #SLE #Lupus #Erythematosus
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus Clinical Domains: • Constitutional domain: Fever • Cutaneous domain: Non-scarring
Classification Criteria ... pericarditis • Hematologic ... domain: Leukopenia, Thrombocytopenia ... #SLE #Systemic ... #diagnosis #rheumatology
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... , oral ulcers, Lupus ... Workup: - ANA ... • Evolution: ... Management #Summary #rheumatology
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Neurological 12% - Thrombocytopenia ... involvement 3% SLE-Related ... Auto-Antibodies: - ANA ... Lupusreference #SLE ... #differential #rheumatology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
Workup: - ANA ... cutaneous-DIL • Evolution ... Workup: - ANA ... • Evolution: ... #table #rheumatology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
function test, ANA ... (e.g., SLE), anti-phospholipid ... - Bone marrow evaluation ... or if a primary hematologic ... Causes #Workup #hematology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
erythematosus [SLE ... leukopenia, anemia, and thrombocytopenia ... Histopathologic criteria ... Diagnosis #Management #Hematology ... #Rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
< 30 years - Aorta ... branches • GCA: - Aorta ... such as systemic lupus ... vasculitis, and SLE ... differential #diagnosis #rheumatology
Drug Induced Lupus (DIL) • Epidemiology: -10% of all lupus cases, drug-dependent, 4:1 to 1:1 F:M
Drug Induced Lupus ... is rare in DIL, SCLE-DIL ... Workup: - ANA ... cutaneous-DIL • Evolution ... #DIL #rheumatology
Relapsing Polychondritis What is it? Recurrent inflammation of the cartilage in the body (Autoimmune disorder) Who? • Most frequently: 40
and fatigue Criteria ... Large vessels (aorta ... cases such as: • SLE ... Nonspecific ↑ ESR, CRP, ANA ... Polychondritis #rheumatology
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