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algorithm differential hematology testing causes iron kawasaki management nutrition pediatrics thrombocytosis b12 carcinoma chronic cobalamin criteria diarrhea disorders gastrointestinal gluten
Gastrointestinal Evaluation of Iron Deficiency Anemia In patients with anemia, diagnose iron deficiency if: • Ferritin <
with anemia, diagnose ... tests Test for celiac ... disease with serology ... #Evaluation #workup ... #diagnosis #gastroenterology
Suspected Celiac Disease - Diagnosis Algorithm Celiac disease suspected: • Signs and symptoms of celiac disease •
Disease - Diagnosis ... disease • Iron-deficiency ... anemia unresponsive ... to treatment ... #Disease #Diagnosis
Commonly Used Diagnostic Tests for Celiac Disease Tissue transglutaminase (tTG) IgA antibodies - Most reliable noninvasive test
Commonly Used Diagnostic ... negative with IgA deficiency ... Reflects response to treatment ... Laboratory #Tests #Diagnosis ... #Workup #Table
Causes of Iron Deficiency • Inadequate Intake: Vegetarian/vegan diet, Malnutrition • Increased Body Needs: Infants/preschoolers, Pregnancy,
Causes of Iron Deficiency ... Pregnancy, EPO treatment ... Loss (without anaemia ... Bleeding, Edema, Celiac ... #differential #diagnosis
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
disorders • Celiac ... disease Tissue ... effect following treatment ... malignancy • Iron deficiency ... anemia #Thrombocytosis
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
hematology for workup ... Acute hemolysis, deficiency ... anemia, Rebound ... effect from treatment ... disease, Kawasaki
Chronic Diarrhea - Workup Osmotic: • Consider food diary and trial avoiding certain foods or meds, Consider
Chronic Diarrhea - Workup ... certain foods or meds ... disease Inflammatory ... Chronic #Diarrhea #Workup ... #testing #evaluation
Celiac Disease Testing Algorithm INDICATIONS FOR TESTING: Nonspecific symptoms (iron-deficiency anemia, failure to thrive, fever, skin
Celiac Disease Testing ... symptoms (iron-deficiency ... anemia, failure ... #Algorithm #diagnosis ... #gastroenterology
Celiac Disease - Diagnosis Algorithm IgA TTG has high sensitivity and specificity of ~ 98% and is
Celiac Disease - ... serologic marker for evaluating ... IgA deficiency affects ... #Disease #Diagnosis ... #workup
Vitamin B12 (Cobalamin) Deficiency Etiology: • Vit B12 - aka cobalamin. Present in foods derived from animal
B12 (Cobalamin) Deficiency ... related to IBD, celiac ... disease, other ... total body stores Evaluation ... Check for IF ab Treatment
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