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diagnosis differential anemia hematology algorithm nutrition classification cobalamin mcv alopecia approach dermatology fe gastroenterology gastrointestinal hair hairloss loss low management
Causes of Iron Deficiency • Inadequate Intake: Vegetarian/vegan diet, Malnutrition • Increased Body Needs: Infants/preschoolers, Pregnancy,
Causes of Iron Deficiency ... Elite athletes • Chronic ... Bleeding, Edema, Celiac ... Disease (IBD, cancer ... ) #Iron #Deficiency
Causes of Iron Deficiency • Diet: ↓ Intake, e.g. vegan, Malnutrition, Polyphenol / tannins, ↓ Vitamin
Causes of Iron Deficiency ... Drugs, H pylori, Celiac ... Inflammation: IBD, Chronic ... disease (↑ hepcidin ... #Deficiency #Causes
Gastrointestinal Evaluation of Iron Deficiency Anemia In patients with anemia, diagnose iron deficiency if: • Ferritin <
Gastrointestinal Evaluation ... of Iron Deficiency ... inflammation or chronic ... tests Test for celiac ... disease with serology
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Low Mean Corpuscular Volume (<80
Causes of Anemia ... Volume (<80 fL) • Iron ... Deficiency • ... (>100 fL) • B12 ... Diagnosis #Algorithm #Causes
Causes of Iron Deficiency - Differential Diagnosis Algorithm • Blood loss: GI (cancer, ulcer, IBD), GU
Causes of Iron Deficiency ... kidney disease, ... of absorption): Celiac ... disease, Bypass ... #Diagnosis #Causes
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Causes of Thrombocytosis ... disorders • Celiac ... disease Tissue ... malignancy • Iron ... deficiency anemia
Causes of Low Vitamin B12 Levels Low vitamin B12 intake - Vegetarianism, chronic alcoholism and older people Autoimmune
Causes of Low Vitamin ... B12 Levels Low ... vitamin B12 intake ... , coeliac disease ... #VitaminB12 #deficiency
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
MCH, MCHC, Serum Iron ... Deficiency • ... B12/Folate Deficiency ... Disease • Marrow ... Diagnosis #Algorithm #Causes
Diagnostic Framework for Anemia (Morphological Approach - MCV) Low MCV - <80fL - "Microcytic" • Iron deficiency
Microcytic" • Iron ... kidney disease, ... Megaloblastic: Vitamin B12 ... Alcohol use, Liver disease ... differential #diagnosis #causes
Allopecia - Differential Diagnosis Framework for Hair Loss Localized / Focal Hair Loss Pattern: • Scarring Alopecia:
Capitis - Skin Disease ... of any comorbid disease ... • Laboratory evaluation ... weight loss • Chronic ... iron deficiency
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