16 results
Managing warfarin INR

Warfarin dosage must be individualized according to the patient's response to the drug, and
response to the drug ... #treatment #medications ... #table #pharmacotherapy ... #hematology #warfarin ... #dosing
Antinuclear Antibodies (ANA)
ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Using fluorescence ... Systemic lupus erythematosus ... (MCTD), Drug-induced ... ANA #patterns #rheumatology ... #diagnosis #differential
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Differential Diagnosis ... vein thrombosis Hematologic ... extremities Drug ... • Antihistone: Drug ... #Diagnosis #Rheumatology
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
Systemic lupus erythematosus ... ) • Sepsis • Drug-induced ... Treatment: • Corticosteroids ... Activation #Syndrome #Diagnosis ... #Management #Hematology
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
Systemic Lupus Erythematosus ... Evolution: Chronic disease ... sle #comparison #table ... #rheumatology # ... diagnosis #management
Drug Induced Systemic Lupus Erythematosus
> 100 drugs have been associated with drug-induced SLE
High risk (>5%):
 •
Lupus Erythematosus ... for 1 year of treatment ... #pharmacology # ... #differential #diagnosis ... #rheumatology
Antinuclear antibodies and Systemic lupus
Anti-dsDNA	60-80%	Association with disease activity (when with Farr assay) and lupus nephritis. Can
also be measured using ... SLE (60-70%) & drug-induced ... Systemic #lupus #erythematosus ... #diagnosis #rheumatology ... #table #ANA
Hypersensitivity Types and Their Mechanisms
Type I - lgE - Soluble antigen
 - Allergen-specific lgE antibodies bind
allergies, and drug ... hemolytic disease ... systemic lupus erythematosus ... Pathophysiology #Allergy #Diagnosis ... #Reactions #Table
Summary of actions of some Cholinergic Agonists

Bethanechol 
• Used in treatment of urinary retention 
• Binds
Produces miosis during ... Edrophonium • Used for diagnosis ... for Alzheimer's disease ... Cholinergic #Agonists #Pharmacology ... #Table #Summary
Scleroderma Like Conditions - Differential Diagnosis
Eosinophilic Fasciitis:
 - Orange peel induration (peau d'orange) of proximal extremities
- Differential Diagnosis ... the mainstay of treatment ... immunocompromised host Drug ... #comparison #table ... #dermatology