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diagnosis differential management symptoms hematology lupus pathophysiology dermatology erythematosus systemic causes syndrome treatment workup table arthritis algorithm ana antinuclear autoantibodies
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
- Drug-induced SLE ... c-ANCA - Vasculitis ... granulomatosis p-ANCA - Vasculitis ... diagnosis #table #rheumatology ... #antibodies
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
Antineutrophil cytoplasmic antibodies ... in drug-induced SLE ... ANCA-Associated Vasculitis ... Renal-limited vasculitis ... #diagnosis #rheumatology
Clinical Manifestations of Systemic Lupus Erythematosus (SLE) #Systemic #Lupus #Erythematosus #SLE #Manifestations #Signs #Symptoms #Rheumatology #Diagnosis
Clinical Manifestations ... Erythematosus (SLE ... Erythematosus #SLE ... Manifestations #Signs ... #Symptoms #Rheumatology
ANA Patterns and Associated Rheumatic Diseases: • Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease
Associated Rheumatic Diseases ... erythematosus (SLE ... connective tissue disease ... #Antinuclear #Antibodies ... ANA #patterns #rheumatology
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antinuclear Antibodies ... Antibody refers to antibodies ... likely it will be clinically ... #Antinuclear #Antibodies ... ANA #patterns #rheumatology
Dermatological semiology of Cutaneous Vasculitis Clinicopathologic correlations • Purpura, papules, pustules, necrosis: involvement of small vessels
Connective tissue disease ... (10%) : SLE +++ ... • IgA vasculitis ... dermatology #semiology #signs ... lesions #diagnosis #clinical
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
(Granulomatous disease ... purpura: strong sign ... C-ANCA) pattern: antibodies ... , and SLE) • Urinalysis ... differential #diagnosis #rheumatology
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Autoimmune • ITP • SLE ... Alloimmune • anti-HLA antibodies ... HUS • DIC • Vasculitis ... Algorithm #Causes #Hematology
Skin Conditions Associated with Joint Pain Rash • Human parvovirus B19 infection Malar rash • SLE • Human parvovirus B19 infection •
Malar rash • SLE ... Hypersensitivity vasculitis ... IBD • RA • SLE ... Antiphospholipid-antibody syndrome • Vasculitis ... differential #diagnosis #rheumatology
Vasculitis Involving the Skin - Differential Diagnosis Framework Primary: 50% Cutaneous Vasculitis: Leukocytoclastic Vasculitis Secondary: CTD: SLE, RA
Vasculitis Involving ... 50% Cutaneous Vasculitis ... Secondary: CTD: SLE ... : • Behcet Disease ... #dermatology #rheumatology
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