ecg qtc syndrome acltear hematology disease differential classification causes diagnosis hepatology nephrology aki rheumatology anemia mcv ascites macrocytic

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Diagnostic Framework for Anemia (Morphological Approach - MCV)
Low MCV - <80fL - "Microcytic"
• Iron deficiency

- "Macrocytic" ... Myelodysplastic syndrome ... #differential # ... diagnosis #causes ... #hematology

Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV

Microcytic (MCV < 80) "TAILS":
• Thalassemia

- Differential ... by MCV Microcytic ... aciduria, Drugs (e.g ... Non-megaloblastic: Liver disease ... Diagnosis #hematology

Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Normal Blood Smear
•

Causes of Anemia ... Corpuscular Volume (MCV ... ) - Differential ... Myelodysplastic Syndromes ... #Causes #Hematology

Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Low Mean Corpuscular Volume (<80

Causes of Anemia ... ) - Differential ... (e.g. ... #MCV #Classification ... #Causes #Hematology

Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Decreased WBCs
- Decreased/NormaI

Causes of Anemia ... Corpuscular Volume (MCV ... ) - Differential ... • Secondary (e.g ... #Causes #Hematology

Causes of Anemia with Low Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Decreased Heme Synthesis or

Causes of Anemia ... ) - Differential ... HgbE, HgbC, etc. ... #Microcytic #Anemia ... #Causes #Hematology

Red Blood Cell (RBC) Morphology
Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),

RBC) Morphology Microcytic ... (sometimes) Macrocytic ... Chemotherapy (e.g ... RBC #Morphology #differential ... #diagnosis #hematology

Overall Approach to Anemia - Differential Diagnosis Algorithm

Blood Loss
• Acute Bleed - Normocytic / Normochromic

- Differential ... Diagnosis Algorithm ... Disease • Marrow ... #Classification ... #Causes #Hematology

Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
- Prior platelet count, family

Diagnosis and Workup ... changes), high MCV ... anemia (vegan, ... #Diagnosis #Causes ... #Workup #hematology

Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
• Mechanical Trauma (Microangiopathic hemolytic anemia):

Diagnostic Framework ... Extravascular Causes ... #differential # ... diagnosis #hematology ... #anemia

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