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algorithm management blood product reactions acidosis atlas bloodcell elevatedmcv elevation embolism extravascular hemolysis hodgkins intravascular lactate lactic lymphoma macrocytic macrocytosis
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Low Mean Corpuscular Volume (<80
Causes of Anemia ... • Bleeding • Hemolysis ... Renal Disease, Liver ... #MCV #Classification ... #Causes #Hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... anemia): ... #differential # ... diagnosis #hematology ... #anemia
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
(e.g. methotrexate ... , Liver disease, ... Microangiopathic Hemolytic ... RBC #Morphology #differential ... #diagnosis #hematology
Differential Diagnosis for Hemolytic Anemia Intrinsic Causes: • Enzyme deficiencies ex. G6PD, pyruvate kinase • Hemoglobinopathies
Differential Diagnosis ... for Hemolytic Anemia ... : • Liver disease ... #Anemia #Differential ... #hematology
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Causes of Anemia ... Diagnosis Algorithm ... Increased Requirement (e.g ... Myelodysplastic Syndromes ... #Causes #Hematology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
DIC/TTP/HUS - Hemolytic ... anemia - Splenomegaly ... deficiency • Liver ... #Diagnosis #hematology ... #nonpalpable #dermatology
Nail Disorders secondary to Systemic Diseases Nail Fold Abnormality • SLE • Scleroderma • Dermatomyositis Koilonychia - Spoon-shaped
discoloration) • Liver ... Systemic #Secondary #dermatology ... #Differential # ... Diagnosis #Algorithm ... #causes
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework VENOUS THROMBOSIS • Acquired Risk Factors: - >48 hours
Myeloproliferative disease ... • Nephrotic Syndrome ... , Ischemic Liver ... Vasculitis • Injury ... pathophysiology #hematology
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis The most common causes of hyperlactatemia are usually:
presentations and disease ... - Compartment syndrome ... ’s • Reduced Arterial ... 30mmHg) - Severe anemia ... #Diagnosis #causes
Blood Transfusion Reactions Immune Mediated: • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
haptoglobin, ↑LDH, etc ... Related Acute Lung Injury ... eruptions, diarrhea, liver ... #Transfusion #diagnosis ... #management #hematology
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