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anemia oncology algorithm atlas management hemolytic key morphology nomenclature workup agglutinin approach basics bleeding bloodcell bruising chronic cll coagulation cold
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Causes Intravascular ... lymphoproliferative disorders ... • Intrinsic RBC ... #Causes #differential ... #diagnosis #hematology
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
Blood Loss ... • Acute Bleed - ... Anemia of Chronic Disease ... Non-lmmune #Anemia #Classification ... #Causes #Hematology
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Infectious: • Acute ... • Rheumatic disorders ... • Celiac disease ... effect following treatment ... #Causes #Hematology
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Causes of Anemia ... Normal Blood Smear ... • Small Bowel Disorder ... Myelodysplastic Syndromes ... #Causes #Hematology
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Red Blood Cell ( ... Chemotherapy (e.g ... Unstable hemoglobin disorders ... #Morphology #differential ... #diagnosis #hematology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
- Differential ... Diagnosis and Workup ... plateletcount), peripheral blood ... Diagnosis #Causes ... #Workup #hematology
Red Blood Cell (RBC) Morphology Atlas • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
Red Blood Cell ( ... Malignant tumors, Acute ... , Disseminated intravascular ... #differential # ... hematology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Cold Agglutinin Syndrome ... younger pts) Differential ... sensitize red blood ... causing intravascular ... hemolytic #anemia #hematology
Causes of Neutropenia - Differential Diagnosis Neonate: - Infection - by far the most common cause -
- Differential ... hypertension and/or drug treatment ... including white blood ... #diagnosis #causes ... #hematology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
malignancy (Especially acute ... ABO incompatible blood ... hydration • RBC ... #causes #treatment ... #management #hematology
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