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causes systemic dermatology elevatedmcv generalized hemolytic liver macrocytosis pruritus thrombocytosis abnormal acidosis agglutinin allergy atlas bloodcell cancer cold common comparison
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
Diagnosis Secondary ... malignancies • Anemia ... Myelodysplastic syndrome ... myeloid leukemia ... #hematology #secondary
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
Chronic leukemia ... develop leukostasis syndrome ... • Tumor lysis syndrome ... #Hematology #Oncology ... #Diagnosis
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Diagnosis Algorithm ... Leukemia, Tumour ... Non-lmmune: • HELLP Syndrome ... #Diagnosis #Algorithm ... #Causes #Hematology
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Low Mean Corpuscular Volume (<80
Diagnosis Algorithm ... of Chronic Disease ... of Chronic Disease ... Diagnosis #Algorithm ... #Causes #Hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
• Neutropenia, anemia ... • Richter’s Syndrome ... syndrome • Smoldering ... #CLL #Chronic ... #oncology #hematology
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
, Chronic disease ... Chemotherapy (e.g ... myeloma Rouleaux: Chronic ... RBC #Morphology #differential ... #diagnosis #hematology
Eosinophilia - Differential Diagnosis Algorithm Idiopathic Eosinophilia Primary Eosinophilia: • Primary hypereosinophilic syndrome • Eosinophilic Leukemia • MPN/MDS
Diagnosis Algorithm ... hypereosinophilic syndrome ... Hyper-lgE (Job) syndrome ... ABPA), Gleich syndrome ... #Diagnosis #Algorithm
Nail Disorders secondary to Systemic Diseases Nail Fold Abnormality • SLE • Scleroderma • Dermatomyositis Koilonychia - Spoon-shaped
Iron deficiency anemia ... discoloration) • Chronic ... • Nephrotic syndrome ... #dermatology #Differential ... #Diagnosis #Algorithm
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
) - HELLP syndrome ... Hemolytic uremic syndrome ... . lupus, CLL, lymphoma ... . sickle cell disease ... #diagnosis #hematology
Pruritus - Generalized Differential Diagnosis Algorithm - Systemic and Primary Causes == Primary Skin Lesions == Macules /
Diagnosis Algorithm ... Creatinine & BUN: • Chronic ... • Lymphoma • Leukemia ... Myelodisplastic syndrome ... Diagnosis #Algorithm
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