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diagnosis causes hemolytic hemolysis extravascular hepatology intravascular rheumatology treatment antibody chronic erythematosus fatigue hemeonc hemophagocytic hepatitis hlh lfts liverenzymes lupus
Autoimmune Hemolytic Anemia (AIHA) WARM AHA - Primary - Idiopathics - Secondary Infectious • Viral- HIV, EBV, HCV, HEV •
Anemia (AIHA) ... Hematopoietic stem ... #AIHA #Diagnosis ... #Differential # ... Algorithm
Warm Antibody Autoimmune Hemolytic Anemia 1) DIAGNOSE AIHA • Anemia: macrocytic > normocytic, ↑ reticulocytes •
Warm Antibody Autoimmune ... 1) DIAGNOSE AIHA ... • Blood smear: Differential ... screening 3) TREAT AIHA ... #diagnosis #management
Autoimmune Hemolytic Anemia (AIHA) Treatment Warm AIHA: 1) Steroids - 1-2 mg/kg prednisone daily • Until
Anemia (AIHA) Treatment ... Warm AIHA: 1) Steroids ... BrighamMedRes #AIHA ... #Anemia #AIHA # ... #hematology
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Immune-Mediated • Warm AIHA ... • Cold AIHA ... • Drug-induced AIHA ... Complement-Mediated • Cold AIHA ... #Causes #Hematology
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Membrane): - Autoimmune ... : Warm AIHA, Cold ... AIHA, Transfusion ... Defects, Drugs, Liver ... #Diagnosis #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
(AIHA) "Warm" ( ... (AIHA)"Cold" (usually ... Extravascular #Causes #differential ... #diagnosis #hematology ... #anemia
Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV Microcytic (MCV < 80) "TAILS": • Thalassemia
Algorithmic Approach ... to Anemia - Differential ... - Extrinsic: Autoimmune ... Non-megaloblastic: Liver ... Diagnosis #hematology
Autoimmune Hepatitis Clinical Presentation - Highly variable clinical presentation, from subclinical disease to acute liver failure. -
injury, though ... AIH-PBC Overlap ... If suspected, AIH ... #Hepatitis #AIH ... #Hepatology
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Elevated Liver Enzymes ... - Differential ... Diagnosis Algorithm ... • Ischemia • Autoimmune ... • Drugs • AIH
Causes of Fatigue - Differential Diagnosis Algorithm Endocrine • Hypo/Hyperthyroidism • Diabetes • Pituitary Insufficiency • Adrenal
Diagnosis Algorithm ... Renal Failure • Liver ... Neoplastic / Hematologic ... • Anemia • ... Hepatitis • HIV Autoimmune
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