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ANCA Associated Vasculitis (AAV) - Auto-antibodies and Differential Diagnosis MPA → usually p-ANCA GPA → usually c-ANCA EGPA →
ANCA Associated ... EGPA → ANCA in ... 40-50% P-ANCA ... (MPO) C-ANCA ( ... PR3) X-ANCA (elastase
ANCA-Associated Vasculitis A group of necrotizing, small-vessel vasculitis without immune complex deposition. Complement levels are normal due
ANCA-Associated ... - C-ANCA pattern ... antibody) - P-ANCA ... Hydralazine-induced ANCA ... @AnnKumfer #ANCA
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
Antibody) and ANCA ... polyangiitis - MPO>PR3 - ANCA ... 80-90%) > MPO - ANCA ... MPO: 75-80% - ANCA ... disease - MPO>PR3 - ANCA
Pulmonary Renal Syndrome Definition: Diffuse alveolar hemorrhage + Glomerulonephritis Presentation (Pulmonary and renal manifestations can occur weeks apart):
Pauci-Immune: - ANCA-positive ... polyangiitis) - ANCA-negative ... Disease-specific testing ... : anti-ANCA ab, ... anti-GBM ab, ANA
Chronic Diarrhea - Workup Osmotic: • Consider food diary and trial avoiding certain foods or meds, Consider
A/P, Consider testing ... celiac and/or testing ... for fecal elastase ... TSH, Consider testing ... #differential #testing
Autoantibodies in Rheumatology • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
• Lupus (SLE): ANA ... Polymerase Ill • ANCA ... Vasculitis: P-ANCA ... perinuclear), C-ANCA
Testing for Diabetes Type II - Hemoglobin A1c test - Random blood sugar test - Fasting
Testing for Diabetes ... sugar test - Fasting ... Classification #Testing
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
Associated - ANCA ... Granulomas - ANCA ... Granulomas - ANCA ... Suggest CTD) • ANCA ... (MPO) - (C-ANCA
Approach to managing Glomerulonephritis (GN) in children. ANCA, antineutrophil cytoplasmic antibodies; c-ANCA, cytoplasmic antineutrophil cytoplasmic antibodies;
ANCA, antineutrophil ... antibodies; c-ANCA ... hypertension; p-ANCA
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
Disease Associations ANA ... Graves' disease c-ANCA ... granulomatosis p-ANCA
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