30 results
Warm vs Cold Autoimmune Hemolytic Anemia
Warm Autoimmune Hemolytic Anemia:
 • Mechanism: IgG and Complement-mediated
 • Etiology:
Anemia Warm Autoimmune ... Hemolytic Anemia ... Anemia: • Mechanism ... #Anemia #hematology ... #diagnosis #comparison
Pathophysiology, Signs and Symptoms of Hemolytic Anemia

#Pathophysiology #Hemolytic #Anemia #hematology #diagnosis #signs #symptoms
Pathophysiology, Signs and Symptoms ... of Hemolytic Anemia ... Pathophysiology #Hemolytic ... #Anemia #hematology ... diagnosis #signs #symptoms
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
Framework for Hemolysis ... Intravascular Hemolysis ... anemia): ... usually IgG) (e.g. lupus ... diagnosis #hematology #anemia
SLICC SLE Diagnostic Criteria - Systemic Lupus Erythematosus
Clinical and Immunologic Criteria

CLINICAL CRITERIA
 - ACUTE CUTANEOUS LUPUS
Criteria - Systemic Lupus ... NEUROLOGIC - HEMOLYTIC ... ANEMIA - LEUKOPENIA ... the absence of hemolytic ... anemia #Diagnosis
Autoimmune Hemolytic Anemia (AIHA)

WARM AHA
- Primary - Idiopathics
- Secondary
Infectious
 • Viral- HIV, EBV, HCV, HEV
 •
Autoimmune Hemolytic ... Anemia (AIHA) ... Autoimmune • Lupus ... #Autoimmune #Hemolytic ... #Anemia #AIHA #
Systemic Lupus Erythematosus - Diagnosis
Manifestations:
 - Arthritis 69%
 - Malar rash 40%
 - Fever 36%
 -
Systemic Lupus Erythematosus ... Lymphadenopathies 7% - Hemolytic ... anemia 4% - Myositis ... Diagnosis and Lupus ... autoantibodies #signs #symptoms
Clinical Features of Systemic Lupus (SLE)
General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%)
Eye: Sjögrens (15%)
Skin
Features of Systemic Lupus ... ) Blood (75%): Anemia ... normochromic nomocytic or haemolytic ... Thrombocytopenia #Lupus ... erythematosus #signs #symptoms
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
(Cold-induced symptoms ... of anemia include ... Diagnosis: • hemolytic ... anemia • Cold ... #anemia #hematology
Elevated Lactate Dehydrogenase (LDH) - Differential Diagnosis Framework

LDH is a cytoplasmic enzyme present in tissues throughout
: • Hemolytic ... Anemias: - Spherocytosis ... anemia, PNH, immune ... - Pernicious anemia ... associated with any symptoms
Pancytopenia - Differential Diagnosis

Congenital Diseases:
• GATA2 deficiency
• Fanconi’s anemia
• Wiskott-Aldrich syndrome
• Ribosomopathy or telomeropathy

Cancer:
• Leukemia
• Lymphoma

Inflammatory
deficiency • Fanconi’s anemia ... Diseases: • Systemic lupus ... Antibody-mediated hemolysis