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Systemic Lupus Erythematosus - Diagnosis
Manifestations:
 - Arthritis 69%
 - Malar rash 40%
 - Fever 36%
 -
Malar rash 40% - Fever ... Myositis 4% - Lung ... Diagnosis and Lupus ... autoantibodies #signs ... #symptoms #mimickers
Systemic Lupus Erythematosus: Gastrointestinal Manifestations
 - Thrombosis of vessels in the pancreas, Vasculitis -> Acute Pancreatitis
Pancreatitis - Elevated Liver ... Pseudo-Obstruction: Abdominal pain ... Erythematosus #SLE ... pathophysiology #signs ... #symptoms #diagnosis
Clinical Features of Systemic Lupus (SLE)
General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%)
Eye: Sjögrens (15%)
Skin
effusion, Restrictive lung ... lesions Abdominal pain ... (20%) Renal disease ... erythematosus #signs ... #symptoms #diagnosis
Skin Conditions Associated with Joint Pain

Rash
	• Human parvovirus B19 infection

Malar rash
	• SLE
	• Human parvovirus B19 infection
	•
• Rheumatic fever ... lesions • Discoid lupus ... dermatology #joint #pain ... #skin #rashes #differential ... #diagnosis #rheumatology
Antinuclear Antibodies (ANA)
ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
assay (IFA) is the main ... context of other symptoms ... : Lupus (SLE), Systemic ... #rheumatology #diagnosis ... #differential
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... permanent alopecia Differential ... Diagnosis: • ANCA-associated ... Arthritis: • Joint pain ... : • Symptoms limited
Extra-articular and Other Conditions Associated with Joint Pain

Eyes
  • Iritis or uveitis - Spondyloarthropathies, Sarcoidosis,
Associated with Joint Pain ... • Interstitial lung ... • Shrinking lung ... #differential # ... diagnosis #rheumatology
Common organ involvements and symptoms in Sarcoidosis
Lung 89-99% - Cough, dyspnoea, wheezing and stridor
Skin 16-32% -
in Sarcoidosis Lung ... Skin 16-32% - Lupus ... 20% - Abdominal pain ... 10% - Abdominal pain ... #diagnosis #signs
Bilateral B-Lines in case of Pneumonia on Lung POCUS

Young healthy pt with fever/dyspnea. POCUS lung exam
POCUS lung exam ... Differential Bilat ... disease, interstitial ... partially seen shred sign ... NOT definitively diagnose
Biphasic Illness of Leptospirosis
Some patients do not progress to severe disease. Others, rapidly develop severe disease
brief interval symptom ... suffusion (redness w/o exudate ... vomiting, abdominal pain ... Biphasic #Phases #Diagnosis ... #Illness #Signs