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Review of the Coagulation Cascade Traditional Model: • Parallel extrinsic and intrinsic pathways. Contemporary Model: • 4 key
activated clotting factor ... Initiation phase caused ... by tissue factor's ... cross-linked by Factor ... models #hematology #pathophysiology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Consumption of Clotting Factors ... Reduced levels of factors ... protein C and S Pathophysiology ... Treat primary cause ... Coagulation #diagnosis #causes
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework VENOUS THROMBOSIS • Acquired Risk Factors: - >48 hours
Acquired Risk Factors ... Thrombophilia: - Factor ... cardiovascular risk factors ... coagulation and other causes ... Venous #Arterial #pathophysiology
NSAID vs ACEI/ARB effects on the Kidneys Remember that NSAIDs and ACEI/ARB therapy have opposing effects on
NSAIDs cause vasoconstriction ... use shouldn't cause ... additional risk factors ... Nephrology #Renal #Pathophysiology
Causes of Atrial Fibrillation Heart disease - Aging heart - Cardiomyopathies - Congestive heart
Causes of Atrial ... Extracardiac factors ... AFib #Cardiology #Pathophysiology
TRALI vs TACO - Transfusion Reactions TRALI: • Epidemiology: 0.1% of transfused patientsl • Risk factors: Critical
patientsl • Risk factors ... blood donor • Pathophysiology ... without other cause ... patients • Risk factors ... transfusion • Pathophysiology
Causes of B12 deficiency. This great diagram shows normal absorption and outlines most possible causes. At
Causes of B12 deficiency ... most possible causes ... bind to intrinsic factor ... #Differential #Causes ... #Diagnosis #Pathophysiology
Refeeding Syndrome Overview What Is It? • Electrolyte/fluid shifts caused by initiation of nutrition in severely malnourished patient.
Electrolyte/fluid shifts caused ... changes and may cause ... Risk Factors: ... are the leading cause ... Differential #Diagnosis #Pathophysiology
Pisa Syndrome (pleurothotonus) on Physical Exam A tonic flexion of the trunk of the body to one
Caused commonly ... Pathophysiology: ... Risk factors: age
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 Posterior Reversible Encephalopathy Syndrome (PRES) Overview Clinico-Radiological Syndrome, characterized by: • Headache • Seizures • Altered mental
Etiology: • Pathophysiology ... precipitating factor ... Risk factors 3. ... the underlying cause ... with AEDs until cause
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