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Von Willebrand Disease - Most common inherited bleeding disorder Clinical • Easy bruising •
bleeding disorder Clinical ... prolonged if very low factor ... Disease #Diagnosis #Hematology
Bleeding risk calculators - HAS-BLED (atrial fibrillation) and IMPROVE (VTE prophylaxis for inpatients) Important notes: • No
studies suggest net clinical ... Anticoagulation #Factors ... #Hematology #Diagnosis
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Consumption of Clotting Factors ... Reduced levels of factors ... Exposure → Tissue factor ... organ damage Clinical ... treatment #management #hematology
REBEL Review 79: Treatment of Hemophilia Walkina Out of Pt Room, You Should Know... 1. Type
Factor Activity ... Type of Factor ... ) Units of Factor ... #hemophilia #hematology ... #factorix
Cryofibrinogenemia Summary Cryofibrinogenemia Epidemiology: • 40-70 years with a modest female predominance Cryofibrinogenemia: • The precipitation of a
insoluble globulin - Factor ... depletion of clotting factors ... Cryofibrinogenemia Clinical ... Diagnosis: • + Clinical ... #hematology
Heparin Induced Thrombocytopenia (HIT) - Diagnosis and Management - GrepMed Handbook Presentation: • Plts ↓50% (nadir
sites) ↑ Risk Factors ... Diagnosis: • Clinical ... non-heparin A/C if clinical ... Management #Treatment #Hematology
Hemostasis Physiology The blood's response to blood vessel injury can be viewed as four interrelated steps. Roman
to coagulation factors ... PF-3, platelet factor ... Coagulation #Cascade #Hematology
Mixing Study • Clotting tests can be abnormal due to either a clotting factor deficiency, or
either a clotting factor ... inhibitor of normal factor ... Patient has a factor ... Study #diagnosis #hematology ... pathophysiology #hematology
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
could be multiple factors ... pathways or a single factor ... Decreased factor ... Factor consumption ... #differential #hematology
Anticoagulants Common Reversal Agents - Warfarin (Coumadin) → Vitamin K (Phytonadione), 4-factor PCC (Kcentra) - Heparin/LMWH
Phytonadione), 4-factor ... alfa (Andexxa), 4-factor ... #pharmacology #hematology
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