1575 results
REBEL Review 79: Treatment of Hemophilia 

Walkina Out of Pt Room, You Should Know... 
1. Type
Factor Activity ... Type of Factor ... ) Units of Factor ... #hemophilia #hematology ... #factorix
Hemostasis Physiology

The blood's response to blood vessel injury can be viewed as four interrelated steps. 
Roman
to coagulation factors ... PF-3, platelet factor ... Coagulation #Cascade #Hematology
Mixing Study
 • Clotting tests can be abnormal due to either a clotting factor deficiency, or
either a clotting factor ... inhibitor of normal factor ... Patient has a factor ... Study #diagnosis #hematology ... pathophysiology #hematology
Differential Diagnosis for a Prolonged PT and aPTT
If the PT and the aPTT are both prolonged,
could be multiple factors ... pathways or a single factor ... Decreased factor ... Factor consumption ... #differential #hematology
Coagulation Cascade Mnemonic - PITT vs PET
PITT (with an I) = Intrinsic = APTT
Intrinsic = APTT Factors ... Extrinsic=PT Factors ... Common Pathway: Factors ... PET #diagnosis #hematology
Anticoagulants Common Reversal Agents
 - Warfarin (Coumadin) → Vitamin K (Phytonadione), 4-factor PCC (Kcentra)
 - Heparin/LMWH
Phytonadione), 4-factor ... alfa (Andexxa), 4-factor ... #pharmacology #hematology
Blood Product Components, Contents, Volume and Shelf Life

Whole blood (autologous or directed donations) - RBC and
Factors V and VIII ... all coagulation factors ... least 80 units of factor ... von Willebrand factor ... Contents #Volume #Hematology
Hemophilia - Diagnosis and Management
Diagnosis:
 • Consistent bleeding history (unless screening for disease in family members
von Willebrand factor ... normal Individual factor ... with relevant factor ... Serious: 100% factor ... Management #treatment #hematology
Review of the Coagulation Cascade
Traditional Model:
 • Parallel extrinsic and intrinsic pathways.
Contemporary Model:
 • 4 key
activated clotting factor ... caused by tissue factor's ... intrinsic X-ase; factors ... cross-linked by Factor ... diagnosis #models #hematology
Prothrombin Time (PT) and Partial Thromboplastin Time (PTT)

Prothrombin Time (PT) - Often Elevated in:
 • Vitamin
(warfarin) • Factor ... Heparinized line • Factor ... test tubes • Factor ... Thromboplastin #laboratory #hematology