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diagnosis hematology coagulation differential pt causes disseminated intravascular abnormal laboratory management prolonged anticoagulant anticoagulation apixaban bleeding bruising cascade clot dabigatran
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
and/or aPTT Prolonged ... typically prolong aPTT ... may prolong the aPTT ... aPTT 1. ... intravascular coagulation (DIC
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
and aPTT If the ... PT and the aPTT ... , FVII, FIX, FX ... intravascularcoagulation (DIC ... #aPTT #Prolonged
Prothrombin Time (PT) and Partial Thromboplastin Time (PTT) Prothrombin Time (PT) - Often Elevated in: • Vitamin
Thromboplastin Time (PTT ... warfarin) • Factor VII ... Thromboplastin Time (PTT ... elevated in: • DIC ... #PTT #Prothrombin
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Intravascular Coagulation (DIC ... /PTT • Low plasma ... levels of factors VII ... /INR: ↑ • PTT: ... INR < 2.3 - APTT
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
/NORMAL PTT: • ... /ABNORMAL PTT: ... Perform a PTT mixing ... /NORMAL PTT: Suggests ... PTT suggests liver
ISTH Scoring System for Disseminated Intravascular Coagulation (DIC) Platelet count: • Expected: Low (or normal) • Elevation
Intravascular Coagulation (DIC ... platelet aggregation PT ... , aPTT: • Expected ... using INR use PT ... small vessels #DIC
Therefore, studies obtained at the initial presentation in the emergency department should evaluate for fibrinolysis with
prothrombin time (PT ... thromboplastin time (PTT ... decompensated DIC ... Diagnosis #Honc #DIC
The coagulation cascade is shown, separated into different phases with their endogenous and pharmacological inhibitors shown.
complexes with FVIIa ... TF-FVIIa also activates ... thrombin #clot #PT ... #PTT #diagnosis
Postpartum Hemorrhage - Differential Diagnosis and Management Uterine Atony (80%) - Most PPH Will respond to
epinephrine prn DIC ... CBC, fibrinogen, PT ... /PTT • Treat with
Ear Pain (Otalgia) - Differential Diagnosis Framework Primary Otalgia - Pain that originates from the ear
Cranial nerve VII ... torticollis, cervical disc ... artery aneurysm, Pott
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