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diagnosis hematology coagulation algorithm differential causes pt abnormal anticoagulant anticoagulation cascade laboratory management platelet prolonged ptt abuse apixaban bleeding bruising
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Abnormal PT and/or aPTT ... typically prolong aPTT ... may prolong the aPTT ... Prolonged PT and aPTT ... #Abnormal #PT #aPTT
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
Prolonged PT and aPTT ... the PT and the aPTT ... , FVII, FIX, FX ... , FVII, FIX, FX) ... #Abnormal #PT #aPTT
Algorithm for Investigation of Abnormal Coagulation Tests - Prolonged PT - Prolonged aPTT and Prolonged PT - Prolonged aPTT Dr.
PT - Prolonged aPTT ... PT - Prolonged aPTT ... Coagulation #Abnormal #APTT ... Hematology #Diagnosis #Workup
Chest Pain - Diagnosis and Workup Algorithm History and Exam Acute life-threatening causes: • Acute myocardial infarction •
Diagnosis and Workup ... rupture Initial workup ... LET, lipase, PT. aPTT ... Diagnosis #Algorithm #workup
Pancytopenia - Differential Diagnosis Algorithm • 12-13 g/dL, • ANC < 1800/uL, • platelet < 150,000/uL Initial
/uL Initial Workup ... iron studies, PT/aPTT ... Algorithm #hematology #workup
Prothrombin Time (PT) and Partial Thromboplastin Time (PTT) Prothrombin Time (PT) - Often Elevated in: • Vitamin
Thromboplastin Time (PTT ... warfarin) • Factor VII ... Thromboplastin Time (PTT ... thematttsai #PT #PTT
Standardized Physical Abuse Guideline <6 months of age • Social work consult • Skeletal survey • Head
age • Social work ... appearance • CBC, PT, PTT ... Abuse #Guidelines #Workup
Approach to the Hypercoagulable State Arterial thromboembolism → Cardiac rhythm monitoring, Echocardiogram, Vascular imaging → Test for APS, particularly
- No other workup ... screening, CBC, aPTT ... Hypercoagulable #Workup
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
• Prolonged PT/PTT ... levels of factors VII ... PT/INR: ↑ • PTT ... INR < 2.3 - APTT
Algorithm for managing FVII deficiency. *Mild bleeding history includes minor epistaxis, menorrhagia, gastrointestinal bleeding, joint and soft
Algorithm for managing FVII ... #FVII #deficiency ... #FactorVII #Factor7
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