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differential hematology causes algorithm management oncology hemolytic rheumatology chronic classification clinical nephrology syndrome workup atlas cll hemeonc hemolysis infectiousdiseases leukemia
Hemolytic Anemias - Differential Diagnosis Algorithm Signs of anemia and hemolysis: • ↓ Haptoglobin • ↑ LDH
- Differential Diagnosis ... Algorithm Signs ... Reticulocytes • Abnormal ... Hypersplenism, Infection ... #Algorithm #hematology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
, autoimmune disorder ... nose, ears, or fingers ... • Symptoms of anemia ... anemia • Cold ... #hematology #diagnosis
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
- Differential Diagnosis ... • Small Bowel Disorder ... • Pancreatic Disease ... Deficiency - Abnormal ... • Liver Disease
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Low Mean Corpuscular Volume (<80
- Differential Diagnosis ... Normal Mean Corpuscular ... Inflammation, Chronic Infection ... #Differential #Diagnosis ... Algorithm #Causes #Hematology
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
- Differential Diagnosis ... RBC Production - Normal ... Disease • Marrow ... • RBC Membrane Disorder ... RBC Metabolism Disorder
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... Microangiopathic hemolytic anemia ... lymphoproliferative disorders ... #differential #diagnosis ... #hematology #anemia
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
- Differential Diagnosis ... - Hemolytic anemia ... SLE) - Viral infections ... APLS • Acute Infectious ... #Differential #Diagnosis
Skin Ulcers by Etiology - Differential Diagnosis Algorithm Physical: • Trauma • Pressure • Radiation Vascular: • Arterial
• Factitious disorder ... • Sickle Cell Anemia ... Cryoglobulinemia Infectious ... Ulcers #ulcerative #skinrash ... #dermatology #Differential
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
- Differential Diagnosis ... Myelofibrosis Infectious ... • Rheumatic disorders ... • Celiac disease ... Iron deficiency anemia
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... - Differential Diagnosis ... inclusions - If infection ... Consider RBC membrane disorder ... #Differential #Diagnosis
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