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diagnosis hemophagocytic hlh lymphohistiocytosis treatment differential extravascular hemolysis anemia coagulation complications dic disseminated hemeonc hemolytic manifestations sicklecell sjogrens summary syndrome
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Causes of Extravascular ... Differential Diagnosis Algorithm ... Cold AIHA • Alloimmune ... Differential #Diagnosis #Algorithm ... #Causes #Hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Causes Intravascular ... idiopathic) - Autoimmune ... usually IgM) (e.g. primary ... #Causes #differential ... #diagnosis #hematology
Algorithm for the Evaluation and Management of Sickle Cell Crises Clinical Manifestations and Management #Diagnosis #Management #Hematology #SickleCell
Algorithm for the ... of Sickle Cell Crises ... #Hematology #SickleCell ... Manifestations #Workup #Algorithm ... #Ddxof
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Disseminated Intravascular ... Treatment: • Treat primary ... cause • Correct ... #treatment #management ... #hematology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
assessment+++ Primary ... lymphoma (DLBCL, intravascular ... solid cancers • Autoimmune ... Lymphohistiocytosis #diagnosis #management ... treatment #summary #rheumatology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
be any age) Autoimmune ... Hypocomplementemia • Can cause ... Nephrogenic DI Hematologic ... Sjogrens #Syndrome #Rheumatology ... #Diagnosis #Management
Hemophagocytic Lymphohistiocytosis (HLH) Treatment Primary HLH: - HLH-94 Protocol • Dexamethasone
HLH) Treatment Primary ... with infection or autoimmune ... Options for severe cases ... HLH #Treatment #management ... #hematology
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
hyperinflammatory syndrome caused ... Types of HLH • Primary ... Malignancies ▪ Autoimmune ... Infections, malignancy, autoimmune ... #Hematology #HemeOnc
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