13 results
diagnosis hematology oncology algorithm cold agglutinin autoimmune calculation causes classification deficiency disease folate folicacid gammopathy gap globulin hodgkins index leukemia
Warm vs Cold Autoimmune Hemolytic Anemia Warm Autoimmune Hemolytic Anemia: • Mechanism: IgG and Complement-mediated • Etiology:
Hemolytic Anemia ... Complement-mediated • Etiology ... Complement-mediated • Etiology ... #Anemia #hematology ... #diagnosis #comparison
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased WBCs - Decreased/NormaI
Volume (MCV) - Differential ... Bleed • Hemolysis ... Inflammation • Cancer ... #Differential # ... Algorithm #Causes #Hematology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
- Idiopathic monoclonal ... • Symptoms of anemia ... anemia • Cold ... younger pts) Differential ... #anemia #hematology
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
infiltration (e.g. cancer ... Retroperitoneal, Uterine • Hemolysis ... Microangiopathic hemolytic ... Production #Index #hematology ... #anemia #differential
Pancytopenia - Differential Diagnosis Congenital Diseases: • GATA2 deficiency • Fanconi’s anemia • Wiskott-Aldrich syndrome • Ribosomopathy or telomeropathy Cancer: • Leukemia • Lymphoma Inflammatory
Pancytopenia - Differential ... deficiency • Fanconi’s anemia ... telomeropathy Cancer ... Antibody-mediated hemolysis ... #Diagnosis #Hematology
Monoclonal Gammopathy of Undetermined Significance (MGUS) - Summary Framework Hematologic disorder characterized by the presence of either
the hematologic cancer ... No evidence of anemia ... insufficiency, Anemia ... #Significance #hematology ... #diagnosis #oncology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
Platelet Count - Differential ... blood loss, Acute hemolysis ... , deficiency anemia ... Malignancy: Metastatic cancer ... Thrombocytosis #Platelets #Differential
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
• Coombs (-) hemolytic ... anemia due to cold ... Paraproteinemias #Hematology ... #Monoclonal #Differential ... #Diagnosis #Oncology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... Etiology: • Vascular ... DIC/TTP/HUS - Hemolytic ... anemia - Splenomegaly ... #nonpalpable #dermatology
Etiologies of Folate Deficiency • Decreased dietary intake - uncommon in this era • Increased requirements
pregnant have hemolytic ... anemia, or psoriasis ... with leading to a functional ... deficiency #FolicAcid #differential ... #diagnosis #hematology
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