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diagnosis differential causes algorithm hematology anemia infarction spleen splenic approach classification comparison cyanosis defects electrophoresis erythrocytosis ffp hemoglobin hemoglobinopathies hyperferritinemia
Table of hemoglobin defects Alpha-Thal-2 Alpha-Thal-1 Hb H disease Beta-thal minor Beta-thal major Beta-thal intermediate Hb E trait Hb
hemoglobin #defects #hemoglobinopathy
Etiology of Splenic Infarction: • Hypercoagulability: Factor V Leiden, Antiphospholipid syndrome, Malignancy • Embolic disease: Atrial
Gaucher disease • Hemoglobinopathy
Causes of Cyanosis in the Newborn - Differential Diagnosis Algorithm Peripheral Only: • Poor Perfusion • Acrocyanosis Hemoglobinopathy:
Acrocyanosis Hemoglobinopathy
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased WBCs - Decreased/NormaI
Cells • Hemoglobinopathy
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
Congenital • Hemoglobinopathy
Causes of Polycythemia (Erythrocytosis) - Differential Diagnosis Algorithm Relative - Normal RBC Mass / Decreased Plasma Volume
• Congenital Hemoglobinopathy
Causes of Splenic Infarcts - Differential Diagnosis • Myeloid disorders: Myeloproliferative neoplasms (myelofibrosis, polycythemia vera, essential
• Lymphomas • Hemoglobinopathy
Conditions Associated With Hyperferritinemia DDx of extreme hyperferritinemia >10,000 Not just HLH - in fact, most common
Malignancy - Hemoglobinopathy
Indications for Transfusion Packed RBCs • Hgb <7 g/dL or hematocrit <21% in a patient with uncompromised
disease, sepsis, or hemoglobinopathy
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