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hematology management differential anemia algorithm workup atlas blood causes chronic clinical extravascular heartfailure hemolysis hfref intravascular iron leukemia lymphocytic morphology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... ) (e.g. lupus, CLL ... • Intrinsic RBC ... G6PD deficiency) ... #hematology #anemia
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Burr Cell RBC (Echinocyte ... Microangiopathic Hemolytic ... Bite Cell RBC: G6PD ... #differential #diagnosis ... #hematology #microscopy
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
- Differential Diagnosis ... • Sickle cell ... elliptocytosis - RBC ... • PK deficiency ... #Differential #Diagnosis
Common RBC Inclusions and Associations • Howell Jolly Bodies: Hyposplenism, Asplenism, Severe hemolytic anemia • Heinz
Common RBC Inclusions ... Heinz Bodies: G6PD deficiency ... Thalassemia, Sickle cell ... #Bodies #diagnosis ... #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
- Differential Diagnosis ... Consider sickle cell ... hypertension • Unusual RBC ... acanthocytes - Consider RBC ... #Differential #Diagnosis
Red Blood Cell (RBC) Morphology Atlas • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
RBC) Morphology ... spherocytosis, Hemolytic ... Schistocytes - Hemolytic ... Morphology #Atlas #key #diagnosis ... #differential #hematology
Iron Deficiency in Heart Failure - Diagnosis and Treatment Algorithm Diagnosis: Ferritin <100 ng/mL (absolute ID) OR
and Treatment Algorithm ... NYHA class II and Ill ... HF with iron deficiency ... #algorithm #cardiology ... #treatment #guidelines
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
transform into a RBC ... anemia, Intrinsic RBC ... defects (e.g. sickle cell ... anemia, G6PD deficiency ... #differential #diagnosis
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Diagnosis: • ... Lymphocytosis on CBC ... microglobulin Treatment ... #workup #oncology ... #hematology
Iron Deficiency in Heart Failure Pathophysiology: Chronic heart failure leads to an increase in inflammatory cytokines → Inflammation
Iron Deficiency ... and iron release Diagnosis ... functional ID) Treatment ... #CHF #HFrEF #heartfailure ... #cardiology
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