91 results
diagnosis management differential algorithm hematology causes anemia nutrition celiac classification iron nephrology workup crohns hepatology hyperkalemia rheumatology blood clinical gastroesophageal
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... Consider sickle cell disease ... , Hemoglobin H disease ... elliptocytosis, autoimmune hemolysis ... ARUPConsult @ARUPLabs #Hemolytic
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Framework for Hemolysis ... cold agglutin disease ... G6PD deficiency) ... e.g. sickle cell disease ... Hypersplenism, Wilson's disease
Hemolytic Anemia - Differential Diagnosis Algorithm Hereditary: • Peripheral blood smear + DAT + further History •
Hemolytic Anemia ... DAT (-) → G6PD Deficiency ... Immune mediated hemolysis ... malignancy, autoimmune disease ... Microangiopathic hemolytic
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
RBC: Pyridoxine deficiency ... Thalassemia, Iron deficiency ... Microangiopathic Hemolytic ... spherocytosis, Autoimmune hemolytic ... Cold autoimmune hemolytic
Red Blood Cell (RBC) Morphology Atlas • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
Microcytic - Iron-deficiency ... anemia, Liver diseases ... spherocytosis, Hemolytic ... , Liver diseases ... Schistocytes - Hemolytic
Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV Microcytic (MCV < 80) "TAILS": • Thalassemia
inflammation) • Iron deficiency ... -100): • Non-hemolytic ... anemia, CKD • Hemolytic ... , B12 deficiency ... Non-megaloblastic: Liver disease
Autoimmune Hemolytic Anemia (AIHA) Treatment Warm AIHA: 1) Steroids - 1-2 mg/kg prednisone daily • Until
Autoimmune Hemolytic ... Anemia (AIHA) Treatment ... > 10, no more hemolysis ... esp if severe disease ... #Anemia #AIHA #Treatment
Peripheral Blood Smear Analysis Hypochromia Megaloblastic Anemia Schistocytes: Microangiopathic hemolytic anemia (e.g. DIC, TTP, HUS) Microspherocytes: Autoimmune hemolytic anemia Sickled red
Microangiopathic hemolytic ... Microspherocytes: Autoimmune hemolytic ... cells: Sickle cell disease ... Bite cells: G6PD deficiency
Elevated Lactate Dehydrogenase (LDH) - Differential Diagnosis Framework LDH is a cytoplasmic enzyme present in tissues throughout
, deficiency of ... anemia, folic acid deficiency ... - Iron deficiency ... • Legionnaires disease ... or particular disease
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Low Mean Corpuscular Volume (<80
80 fL) • Iron Deficiency ... • Bleeding • Hemolysis ... Renal Disease, Liver ... 100 fL) • B12 Deficiency ... • Folate Deficiency
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