147 results
Paget's Disease of Bone

 • Characterized by an ↑ rate of bone turnover with both excessive
Paget's Disease of Bone ... by an ↑ rate of bone ... and formation of bone ... • Caused by ( ... more (polystotic) bones
Causes of Bone/Joint Pain in Sickle Cell Disease
Vaso-occlusive pain:
 • Mechanism: ischemic pain
 • Can present
Causes of Bone/Joint ... Generally affects long bones ... BrighamChiefs #Bone ... differential #diagnosis #causes
Low Alkaline Phosphatase - Hypophosphatasia 

Is Low Alkaline Phosphatase Of Clinical Importance?

ALP enzyme- Discovered in 1923
Low
synthesized in: liver, bone ... • softening of bones ... of feet, thigh bones ... : Inhibitor of bone ... Skeletal: - Bone
Paget’s Disease: Complications
Abnormal Osteoclasts cause excessive bone turnover -> Incr bone resorption, Incr (abnormal) bone formation

MSK
excessive bone ... turnover -> Incr bone ... Incr (abnormal) bone ... MSK • Deformed bones ... Renal • Incr Bone
Bone Lesion on X-Ray - Differential Diagnosis Algorithm 
Exostotic
 • Osteochondroma
Asymptomatic &/or Non-Active Bone Scam
 •
Bone Lesion on X-Ray ... /or Non-Active Bone ... • Unicameral Bone ... • Aneurysmal Bone ... #Orthopedics #Causes
Primary Bone Tumors - Differential Diagnosis Algorithm 

Metastatic - Most common tumour in adults
 - Breast
Primary Bone Tumors ... • Aneurysmal Bone ... Histiocytoma #Primary #Bone ... #Bony #Tumors # ... #Orthopedics #Causes
Hypercalcemia - Differential Diagnosis Algorithm
Elevated PTH (High or normal):
 • Primary Hyperparathyroidism
 • Familial Hypocalciuric Hypercalcemia
Low
Miscellaneous - Bone ... Hyperthyroid, Bony ... Diagnosis #Algorithm #causes
Rachitic Rosary of Rickets on Physical Exam

Bead-like prominences of bone are seen at the costochondral joints.
prominences of bone ... mineralization causes ... PhysicalExam #clinical #video
SAPHO Syndrome Summary

What?
SAPHO syndrome is a rare chronic inflammatory disorder of bone, joint, and skin characterized
inflammatory disorder of bone ... swelling of the bone ... • Bone and joint ... Rule out other causes ... as the collar bone
Osteomalacia & Osteoporosis in People with HIV
Osteomalacia:
 - Decreased bone matrix mineralization. In people with HIV
- Decreased bone ... (from multiple causes ... ) - Bone pain/ ... of underlying cause ... Osteoporosis: - Loss of bone