6 results
Selected Clinical Trials of SGLT2 inhibitors in CVD and CKD
EMPA-REG OUTCOME - Empagliflozin lowered CV events
inhibitors in CVD ... HF outcomes in HFrEF ... on GDMT, with or ... HF outcomes in HFrEF ... SGLT2 #inhibitors #EBM
Pathophysiological mechanisms of diastolic heart failure HFpEF and possible therapeutic interventions.
Hypertension → Overload
Diabetes → Oxidative stress,
heart failure HFpEF ... RAGE activation CAD ... regulatory reserve → Pulmonary ... #heartfailure #dchf ... #hfpef #pathophysiology
Stages in the development of HF and recommended therapy by stage. ACEI indicates angiotensin-converting enzyme inhibitor;
inhibitor; AF, atrial ... ejection fraction; GDMT ... heart failure; HFpEF ... ejection fraction; HFrEF ... #CHF #Congestive
Heart Failure with Preserved Ejection Fraction: Management Principles

General Therapeutic Principles:
Reduce the congestive state 
 - Caution
sinus rhythm in atrial ... hypertension, pulmonary ... Management #Cardiology #HFpEF ... #dCHF #Diastolic ... #Treatment #HeartFailure
TOPCAT - Spironolactone for Heart Failure with Preserved Ejection Fraction

N Engl J Med 2014; 370:1383-1392 https://www.nejm.org/doi/10.1056/NEJMoa1313731

CONCLUSIONS:
ejection fraction, treatment ... Spironolactone #HFpEF ... #dCHF #Cardiology ... #EBM #VisualAbstract ... #Trial
Iron Deficiency in Heart Failure
Pathophysiology:
Chronic heart failure leads to an increase in inflammatory cytokines → Inflammation
Iron Deficiency ... functional ID) Treatment ... mortality and CV ... #deficiency #CHF ... #HFrEF #heartfailure