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Clinical Manifestations of Human Herpes Viruses (HHV) Herpes simplex virus 1 HSV-1 Frequently subclinical (80-90%) Oral lesions (10-20%) congenital
Clinical Manifestations ... Herpes Viruses (HHV ... herpes virus 6 HHV ... herpes virus 7 HHV ... herpesvirus 8 HHV
HHV8/KSHV-reIated diseases: From Cellular Proliferation to Hyperinflammation Kaposi sarcoma (KS): • Target organs: Ubiquitous (cutaneous and mucosal
HHV8/KSHV-reIated ... predominance) • Clinical ... Light chain: - HHV8 ... and spleen • Clinical ... de Fremont #HHV8
Infection-Related Cancers Viruses: • HPV - Cervical, anogenital, head and neck, skin cancer • HTLV-1 - Adult
Cancers Viruses: • HPV ... T-cell Leukemia • HIV ... cell carcinoma • HBV ... / HCV - Hepatocellular ... carcinoma • HHV
Castleman's Disease and Associated Syndromes HYALINE VASCULAR VARIANT • unicentric, HHV8-ve, children and young. • Hyalinized vessels
• unicentric, HHV8 ... Plasmablastic subtype is HHV8 ... myeloma, POEMS) HHV8
Kaposi Sarcoma Herpes Virus (KSHV) By Dr. Sara Dong @swinndong via #IDFellowCase #ID #Infectious Diseases #Infections #Differential
Diagnosis #KSHV #HHV
Transplant Infections Timeline Pre-transplant: • Common bacteria (endogenous): Staphylococci (skin), Gram-negative bacilli (gut) • Viruses: HSV (reactivation) Engraftment:
gut) • Viruses: HSV ... airways) • Viruses: HSV ... reactivation), HHV
Herpes Virus Antiviral Coverage Pyramid *This chart only covers the herpes virus family, and does not include
Coverage #Pyramid #HSV ... #VZV #HHV6 #HHV7
IDSA Recommendations for Preventing and Treating HHV-8 Diseases—Kaposi Sarcoma (KS), Primary Effusion Lymphoma (PEL), Multicentric Castleman’s
Preventing and Treating HHV ... Disease (MCD) in HIV-AIDS ... and uncontrolled HIV ... activity against HHV ... adjunctive therapy #HHV8
Genital Herpes Simplex - CDC 2021 Treatment Guidelines Recommended Regimens: • First clinical episode of genital herpes
Regimens: • First clinical ... genital herpes (HSV ... genital herpes (HSV ... in persons with HIV ... in persons with HIV
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
accumulation of clinical ... Assessment • Clinical ... Virus (EBV, CMV, HHV8
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