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IDSA Recommendations for Preventing and Treating HHV-8 Diseases—Kaposi Sarcoma (KS), Primary Effusion Lymphoma (PEL), Multicentric Castleman’s
Preventing and Treating HHV ... and uncontrolled HIV ... activity against HHV ... adjunctive therapy #HHV8 ... Prevention #Treatment #management
Clinical Manifestations of Human Herpes Viruses (HHV) Herpes simplex virus 1 HSV-1 Frequently subclinical (80-90%) Oral lesions (10-20%) congenital
Herpes Viruses (HHV ... herpes virus 6 HHV ... herpes virus 7 HHV ... herpesvirus 8 HHV ... Herpes #Viruses #HHV
Infection-Related Cancers Viruses: • HPV - Cervical, anogenital, head and neck, skin cancer • HTLV-1 - Adult
Cancers Viruses: • HPV ... T-cell Leukemia • HIV ... cell carcinoma • HBV ... / HCV - Hepatocellular ... carcinoma • HHV
HHV8/KSHV-reIated diseases: From Cellular Proliferation to Hyperinflammation Kaposi sarcoma (KS): • Target organs: Ubiquitous (cutaneous and mucosal
HHV8/KSHV-reIated ... • Association HIV ... Light chain: - HHV8 ... • Association HIV ... de Fremont #HHV8
Castleman's Disease and Associated Syndromes HYALINE VASCULAR VARIANT • unicentric, HHV8-ve, children and young. • Hyalinized vessels
• unicentric, HHV8 ... Plasmablastic subtype is HHV8 ... myeloma, POEMS) HHV8
Kaposi Sarcoma Herpes Virus (KSHV) By Dr. Sara Dong @swinndong via #IDFellowCase #ID #Infectious Diseases #Infections #Differential
Diagnosis #KSHV #HHV
Transplant Infections Timeline Pre-transplant: • Common bacteria (endogenous): Staphylococci (skin), Gram-negative bacilli (gut) • Viruses: HSV (reactivation) Engraftment:
gut) • Viruses: HSV ... airways) • Viruses: HSV ... reactivation), HHV
SCORTCH Congenital Infections Mnemonic S - Syphilis C - CMV O - Other R - Rubella T - Toxoplasmosis C - Chickenpox
Varicella) H - HSV ... , HIV, HTLV-1, HBV ... , HCV #SCORTCH
IDSA - Prophylaxis to Prevent First Episode of Opportunistic Disease in HIV-AIDS • Pneumocystis pneumonia (PCP)
Opportunistic Disease in HIV-AIDS ... Papillomavirus (HPV ... Hepatitis A virus (HAV ... Hepatitis B virus (HBV ... HIVAIDS #IDSA #management
IDSA - Prophylaxis to Prevent First Episode of Opportunistic Disease in HIV-AIDS • Pneumocystis pneumonia (PCP)
Opportunistic Disease in HIV-AIDS ... Papillomavirus (HPV ... Hepatitis A virus (HAV ... Hepatitis B virus (HBV ... HIVAIDS #IDSA #management
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