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Thrombotic Microangiopathies In Systemic Lupus Erythematosus

Dr. Laurent ARNAUD @Lupusreference

#TMAs #Thrombotic #Microangiopathies #Systemic #Lupus #Erythematosus #SLE #hematology
Erythematosus #SLE ... #hematology #rheumatology ... differential #diagnosis #causes
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary
 • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Erythematosus (SLE ... are evocative of SLE ... Cytopenia: Common • Immunologic ... Positive in 60-80% of cases ... Management #Summary #rheumatology
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
Induced Lupus vs SLE ... drug-dependent) • Immunologic ... Discontinuation of causal ... Cytopenia: Common • Immunologic ... comparison #table #rheumatology
Type III Hypersensitivity: Pathogenesis and clinical findings
Definition: Small antigen-antibody complexes (produced from normal immune response to
self-antigens are the cause ... Erythematosus (SLE ... antigens are the cause ... HypersensitivityReaction #Allergy #Immunology
SLICC SLE Diagnostic Criteria - Systemic Lupus Erythematosus
Clinical and Immunologic Criteria

CLINICAL CRITERIA
 - ACUTE CUTANEOUS LUPUS
SLICC SLE Diagnostic ... Erythematosus Clinical and Immunologic ... <100,000/MM3) IMMUNOLOGIC ... #Diagnosis #Rheumatology ... #SLE #Lupus #Erythematosus
Hydroxychloroquine Serum Measurement in SLE
 • Terminal elimination half-life = 40 days ([HCQI reflects long-term intake)
Measurement in SLE ... suspected) • In case ... • Special cases ... #Measurement #SLE ... #rheumatology #
Causes of Thrombocytopenia - Differential Diagnosis Algorithm
 
Decreased Megakaryopoiesis
 • Aplastic Anemia
 • Toxic Damage (e.g.
Causes of Thrombocytopenia ... Autoimmune • ITP • SLE ... Diagnosis #Algorithm #Causes ... #Hematology
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
• Secondary Causes ... Splenomegaly - CTD (SLE ... Associated - SLE ... Differential #Diagnosis #hematology ... #rheumatology #
Ruptured Chordae Tendineae on POCUS Echocardiogram
 
Many underlying causes, not limited to: MVP, subacute endocarditis, connective
Tendineae on POCUS Echocardiogram ... Many underlying causes ... for MR when you see ... Tendineae #POCUS #Echocardiogram
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
Causes of Thrombocytopenia ... test, ANA (e.g., SLE ... patients if the cause ... Differential #Diagnosis #Causes ... #Workup #hematology