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management differential rheumatology causes algorithm syndrome hepatology clinical dermatology neurology oncology classification hypertension activetb adultonset cirrhosis cll cppd encephalopathy hemeonc
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
- Differential Diagnosis ... Myelofibrosis Infectious ... : • Acute or Chronic ... disorders • Celiac disease ... effect following treatment
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
- Differential Diagnosis ... Rebound effect from treatment ... Vasculitides, IBD, Celiac disease ... : Chronic infections ... #Differential #Diagnosis
Clinical Classification of Pulmonary Hypertension 1. Pulmonary arterial hypertension from pulmonary vasculopathy Idiopathic pulmonary arterial hypertension Heritable gene mutations
- HIV infection ... pulmonary disease ... Chronic thromboembolic ... multifactorial mechanisms Hematologic ... Classification #Diagnosis
Tuberculosis Overview 10 million new M. tuberculosis infections/year Facultative intracellular rod-shaped bacteria Multidrug-resistant tuberculosis (MDR-TB) accounts for 4.6% of
tuberculosis (LTBI) Pathophysiology ... • Silicosis • Chronic ... malignancy, and chronic ... Tuberculosis Diagnosis ... Tuberculosis #TB #Diagnosis
Mycoses HISTOPLASMOSIS • Inhalation of conidia → Yeast → travel to lymph nodes → spread in body • Bird
85% • < 50% in chronic ... extrapulmonary disease ... ) • Chronic, subacute ... Aspergillosis Pathophysiology ... pulmonary infection
Causes of Peripheral Weakness without Sensory Changes - Differential Diagnosis Algorithm No Objective Weakness • Cardio-pulmonary disease
- Differential Diagnosis ... Weakness • Cardio-pulmonary ... disease • Anemia ... • Chronic Infection ... • Endocrine Disease
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Lymphohistiocytosis (HLH) Pathophysiology ... • Autoimmune diseases ... Adult-onset Still disease ... Unknown cause Treatment ... #management #treatment
Adult-Onset Still's Disease Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia + Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Differential Diaqnoses ... : • Infectious ... hepatitis • Pulmonary ... #diagnosis #management ... #treatment #rheumatology
Tuberculosis Overview 10 million new M. tuberculosis infections/year Facultative intracellular rod-shaped bacteria Multidrug-resistant tuberculosis (MDR-TB) accounts for 4.6% of
tuberculosis (LTBI) Pathophysiology ... • Silicosis • Chronic ... malignancy, and chronic ... Tuberculosis Diagnosis ... Tuberculosis #TB #Diagnosis
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic ... months without treatment ... underlying liver disease ... Coagulation Failure Infections ... gastroenterology #management #diagnosis
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