29 results
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Hemophagocytic Lymphohistiocytosis ... (HLH) Pathophysiology ... Hemophagocytic #Lymphohistiocytosis ... #diagnosis #management ... treatment #summary #rheumatology
Hemophagocytic Lymphohistiocytosis (HLH)
Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
Hemophagocytic Lymphohistiocytosis ... can mimic common infections ... Treatment: • Infection ... #diagnosis #management ... #treatment #hematology
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
haemophagocytic lymphohistiocytosis ... hemophagocytic lymphohistiocytosis ... SLE], AOSD) • Infection ... Syndrome #Diagnosis #Management ... #Hematology #Rheumatology
Bandemia Overview

Normal: < 1%
Clinically significant: > 10%

Band neutrophils are slightly less mature than segmented neutrophils and
Neutrophil (Normal) Differential ... overlook severe infections ... #Bandemia #differential ... neutrophil #WBC #CBC #hematology ... #pathophysiology
Rhabdomyolysis - Differential Diagnosis and Management Summary

Trauma:
 • Immobilization, Crush iniury, Compartment syndrome, Electrical injury
Exertional:
 •
Rhabdomyolysis - Differential ... Diagnosis and Management ... Statins), ETOH Infection ... Dermatomyositis) AKI - Pathophysiology ... #Diagnosis #Management
Hemophagocytic Lymphohistiocytosis (HLH) Treatment
Primary HLH:
 - HLH-94 Protocol
    • Dexamethasone
Hemophagocytic Lymphohistiocytosis ... associated with infection ... Hemophagocytic #Lymphohistiocytosis ... HLH #Treatment #management ... #hematology
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
ATRA treatment Pathophysiology ... initiation • Differential ... Diagnosis: Infection ... APML #diagnosis #management ... #hematology #oncology
Adult-Onset Still's Disease
Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia
+ Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
fraction < 20% Differential ... Diaqnoses: • Infectious ... Disease #diagnosis #management ... #treatment #rheumatology
Myasthenic Crisis Checklist - Myasthenia Gravis

Evaluation 
 - Chest X-ray and lung ultrasound (exclude other lung
Myasthenic Crisis Checklist ... Phos), CBC with differential ... possible - Infectious ... if symptoms of infection ... #Management #CriticalCare
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Disease, PRES Pathophysiology ... Lupus Cerebritis Induction ... CNS #neurology #rheumatology ... cerebritis #diagnosis #management