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diagnosis management hematology disease erythematosus lupus systemic treatment antinuclear autoantibodies cold comparison hemeonc neurology sle workup agglutinin anemia arthritis associations
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
ANA - Non-specific ... common in SLE, autoimmune ... #diagnosis #table ... #rheumatology # ... antibodies
Myositis Specific Antibodies (MSAs) Dermatomyositis: MDA5, TIF1y, NXP2, Mi-2, SAE Anti-Synthetase Syndrome: Jo-1, PL7, PL12, EJ, OJ Immune Mediated
Myositis Specific ... , TIF1y, NXP2, Mi ... #clinical #diagnosis ... #rheumatology # ... table
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antinuclear Antibodies ... Positive ANA ≠ Autoimmune ... likely it will be clinically ... but often not specific ... #rheumatology #diagnosis
Antinuclear antibodies and Systemic lupus Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can
Antinuclear antibodies ... Association with disease ... -15% If SLE is clinically ... erythematosus #diagnosis #rheumatology ... #table #ANA
Myasthenia Gravis - Summary • an autoimmune disease of the postsynaptic neuromuscular junction associated with antibodies
autoimmune disease ... Diagnosis: • Based on clinical ... EMG findings • Disease-specific ... have anti—muscle-specific ... - Improves clinical
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Cold Sensitive Antibodies ... Viral infection, autoimmune ... Viral Infection Clinical ... CLL (older) • Autoimmune ... hemolytic #anemia #hematology
Cold Urticaria Prevalence - 0.05% in the population Disease onset - Mostly 2nd to 4th decades of life Causes
of life Causes and ... clinical associations ... Autoimmune diseases ... Urticaria #diagnosis #rheumatology ... #comparison #table
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus Clinical Domains: • Constitutional domain: Fever • Cutaneous domain: Non-scarring
Erythematosus Clinical ... Thrombocytopenia, Autoimmune ... C4 • Highly specific ... antibodies domain ... Erythematosus #diagnosis #rheumatology
Differentiating NBTE from Infective Endocarditis No pathognomonic signs/symptoms or echo features that are specific to NBTE, and
features that are specific ... Predisposing conditions: Autoimmune ... heart valves • MRI ... - Infectious Diseases ... Marantic #diagnosis #table
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
age) Autoimmune ... hypofunction • Antibodies ... Anti-Ro/SSA ab (specific ... salivary ducts Clinical ... Sjogrens #Syndrome #Rheumatology
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