12 results
Myositis Specific Antibodies (MSAs)

Dermatomyositis: MDA5, TIF1y, NXP2, Mi-2, SAE
Anti-Synthetase Syndrome: Jo-1, PL7, PL12, EJ, OJ
Immune Mediated
Myositis Specific ... Antibodies (MSAs ... , TIF1y, NXP2, Mi ... clinical #diagnosis #rheumatology ... #table
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus
Clinical Domains:
 • Constitutional domain: Fever
 • Cutaneous domain: Non-scarring
Systemic Lupus Erythematosus ... C4 • Highly specific ... antibodies domain ... Systemic #Lupus #Erythematosus ... #diagnosis #rheumatology
Antinuclear Antibodies (ANA)
ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antinuclear Antibodies ... Antibody refers to antibodies ... but often not specific ... Systemic lupus erythematosus ... ANA #patterns #rheumatology
Antinuclear antibodies and Systemic lupus
Anti-dsDNA	60-80%	Association with disease activity (when with Farr assay) and lupus nephritis. Can
Antinuclear antibodies ... 60-70% Highly specific ... Systemic #lupus #erythematosus ... #diagnosis #rheumatology ... #table #ANA
Autoantibodies in Rheumatology
 • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
Autoantibodies in Rheumatology ... others (RNP, aPL antibodies ... , Others: SRP, Mi ... Autoantibodies #Rheumatology ... #associations #table
Autoantibodies and their Disease Associations
ANA - Non-specific; common in SLE, autoimmune hepatitis
Anti-CCP, Rheumatoid factor - RA
Anti-dsDNA
Associations ANA - Non-specific ... diseases #diagnosis #table ... #rheumatology # ... antibodies
Hypersensitivity Types and Their Mechanisms
Type I - lgE - Soluble antigen
 - Allergen-specific lgE antibodies bind
antigen - Allergen-specific ... lgE antibodies ... When the specific ... systemic lupus erythematosus ... Diagnosis #Reactions #Table
Summary table of types of hypersensitivity reactions. 
Type 1
 - Mediators: lgE
 - Antigen Form: Soluble
Summary table of ... Action: Allergen-specific ... Action: IgG/lgM antibodies ... Systemic lupus erythematosus ... types #allergy #table
Features That Differentiate Acute Pericarditis from Myocardial Ischemia or Infarction and Pulmonary Embolism

In contrast to the
associated with rheumatologic ... systemic lupus erythematosus ... pain, such as MI ... Presentation #comparison #Table
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
Associated - ANCA specific ... ischemia - Skin: erythematous ... systemic lupus erythematosus ... C-ANCA) pattern: antibodies ... differential #diagnosis #rheumatology