11 results
Myositis Specific Antibodies (MSAs)

Dermatomyositis: MDA5, TIF1y, NXP2, Mi-2, SAE
Anti-Synthetase Syndrome: Jo-1, PL7, PL12, EJ, OJ
Immune Mediated
Myositis Specific Antibodies ... , TIF1y, NXP2, Mi ... Myositis #Specific #Antibodies ... clinical #diagnosis #rheumatology ... #table
Systemic Lupus Erythematosus - Diagnosis
Manifestations:
 - Arthritis 69%
 - Malar rash 40%
 - Fever 36%
 -
Systemic Lupus Erythematosus ... SLE-Related Auto-Antibodies ... Systemic #Lupus #Erythematosus ... autoantibodies #signs #symptoms ... #differential #rheumatology
Antinuclear Antibodies (ANA)
ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antinuclear Antibodies ... Antibody refers to antibodies ... context of other symptoms ... Systemic lupus erythematosus ... ANA #patterns #rheumatology
Autoantibodies in Rheumatology
 • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
Autoantibodies in Rheumatology ... others (RNP, aPL antibodies ... , Others: SRP, Mi ... Autoantibodies #Rheumatology ... #associations #table
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Non-autoimmune rheumatologic ... Induced Lupus: • Symptoms ... 1, SCL-70, RNP antibodies ... anticardiolipin antibodies ... #Diagnosis #Rheumatology
Features That Differentiate Acute Pericarditis from Myocardial Ischemia or Infarction and Pulmonary Embolism

In contrast to the
associated with rheumatologic ... systemic lupus erythematosus ... pain, such as MI ... #Pericarditis #Symptoms ... Presentation #comparison #Table
Antinuclear antibodies and Systemic lupus
Anti-dsDNA	60-80%	Association with disease activity (when with Farr assay) and lupus nephritis. Can
Antinuclear antibodies ... Systemic #lupus #erythematosus ... #diagnosis #rheumatology ... #table #ANA
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
Constitutional symptoms ... constitutional symptoms ... Systemic Lupus Erythematosus ... sle #comparison #table ... #rheumatology #
Congenital Cytomegalovirus Infection- Ultrasonographic images showed ventricular dilatation in the fetal brain, and T2-weighted magnetic resonance
CMV) IgG and IgM antibodies ... asymptomatic, or symptoms ... #clinical #NEJM ... #radiology #MRI
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
ischemia - Skin: erythematous ... systemic lupus erythematosus ... Presentation - Systemic Symptoms ... C-ANCA) pattern: antibodies ... differential #diagnosis #rheumatology