10 results
Autoantibodies and their Disease Associations
ANA - Non-specific; common in SLE, autoimmune hepatitis
Anti-CCP, Rheumatoid factor - RA
Anti-dsDNA
their Disease Associations ... ANA - Non-specific ... #diseases #diagnosis ... #table #rheumatology ... #antibodies
Autoantibodies in Rheumatology
 • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
• Lupus (SLE): ANA ... others (RNP, aPL antibodies ... , Others: SRP, Mi ... #diagnosis #associations ... #table
Antinuclear antibodies and Systemic lupus
Anti-dsDNA	60-80%	Association with disease activity (when with Farr assay) and lupus nephritis. Can
Antinuclear antibodies ... with disease activity ... erythematosus #diagnosis ... #rheumatology # ... table #ANA
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Normal Blood Smear
 •
- Differential Diagnosis ... Algorithm Normal ... • Rule out B12 and ... #Algorithm #Causes ... #Hematology
Cold Urticaria
Prevalence - 0.05% in the population
Disease onset - Mostly 2nd to 4th decades of life
Causes
clinical associations ... Disorientation, vertigo Diagnostic ... Cold #Urticaria #diagnosis ... #rheumatology # ... comparison #table
Rapidly Progressive Glomerulonephritis (RPGN)
RPGN has three primary pathophysiologic causes differentiated by immunofluorescence

Immune Complex Mediated (granular staining):
Purpura Anti-GBM antibodies ... involvement: Anti-GBM Disease ... (C-ANCA): GPA > ... #differential #diagnosis ... #algorithm #rheumatology
Autoimmune Myositis - Differential Diagnosis Framework

Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
- Differential Diagnosis ... RP-ILD), dermato-rheumatologic ... (ANA present 80% ... (also seen in association ... Myositis #Myopathy #rheumatology
Algorithm for choosing the appropriate candidate for stress testing in patients with suspected coronary artery disease
Algorithm for choosing ... coronary artery disease ... (MI = myocardial ... Shows the diagnosis ... evaluation of stable
Crohn's Disease & New Diagnosis of Colon Cancer Algorithm
 - Define Colonic Disease Extent, Activity &
& New Diagnosis ... of Colon Cancer Algorithm ... Activity (MR Pelvis ... ↑ rates intact fertility ... and sexual dysfunction
Anti-NXP-2 Dermatomyositis

What?
DM with generalized subcutaneous edema
Pts have more myalgias, more severe weakness, and an increased prevalence
Antibodies targeting ... had more severe disease ... • Myoglobin Association ... Dermatomyositis #diagnosis ... #management #rheumatology