12 results
Autoantibodies and their Disease Associations
ANA - Non-specific; common in SLE, autoimmune hepatitis
Anti-CCP, Rheumatoid factor - RA
Anti-dsDNA
their Disease Associations ... ANA - Non-specific ... common in SLE, autoimmune ... #diseases #diagnosis ... #table #rheumatology
Autoimmune Hemolytic Anemia (AIHA) - Differential Diagnosis Table

Warm AIHA (48-70%)
Cold AHA (16-32%)
 • Donath-Landsteiner HA (paroxysmal
Autoimmune Hemolytic ... Table Warm AIHA ... (48-70%) Cold AHA ... Cold Agglutinin Disease ... #Table #hematology
Cold Urticaria
Prevalence - 0.05% in the population
Disease onset - Mostly 2nd to 4th decades of life
Causes
clinical associations ... Autoimmune diseases ... Cold #Urticaria #diagnosis ... #rheumatology # ... comparison #table
Autoantibodies in Rheumatology
 • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
Autoantibodies in Rheumatology ... • Lupus (SLE): ANA ... , Others: SRP, Mi ... #diagnosis #associations ... #table
Antinuclear antibodies and Systemic lupus
Anti-dsDNA	60-80%	Association with disease activity (when with Farr assay) and lupus nephritis. Can
with disease activity ... searched for when ANA ... erythematosus #diagnosis ... #rheumatology # ... table #ANA
Multiple Myeloma and Monoclonal Gammopathies
C - HyperCalcemia- calcium > 11 mg/dL / >1 mg/dL the ULN
R
ULN R - Renal disease ... focal lesions on MRI ... autoimmune diseases ... Gammopathies #MGUS #diagnosis ... #hematology #oncology
Inflammatory Myopathies
Dermatomyositis
 • Onset: Subacute
 • Pattern: Proximal
 • CK: Up to 50X ULN
 • Autoantibodies:
Anti-MDA5, anti-Mi ... exclusion Necrotizing Autoimmune ... Pattern: Proximal and ... #comparison #rheumatology ... #table
Erythemas Summarized
Erythema ab igne
 • A dermatosis that results from repeated exposure to heat (fires, heating
early localized disease ... well-described associations ... Classic association ... Erythemas #comparison #table ... #differential #diagnosis
Differentiating NBTE from Infective Endocarditis
No pathognomonic signs/symptoms or echo features that are specific to NBTE, and
Predisposing conditions: Autoimmune ... heart valves • MRI ... often seen • MRI ... - Infectious Diseases ... #table
Idiopathic Inflammatory Myopathies (IIM's)

RASH + MUSCLE WEAKNESS → Consider idiopathic inflammatory myopathies (IIM's)

 • Overlap Myositis
that occurs in association ... features of another autoimmune ... connective tissue disease ... Myopathies #IIMs #diagnosis ... #rheumatology #