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comparison management autoantibodies dermatology differential lupus disease erythematosus sle systemic treatment algorithm antibodies antimda5 antimda5dm antinuclear antinxp2 antinxp2dm autoimmune cancer
Connective tissue disease-associated interstitial lung diseases LIP: lymphoid interstitial pneumonia. NSIP: nonspecific interstitial pneumonia. OP: organizing pneumonia.
DM/PM : dermatomyositis ... ConnectiveTissueDiseases #ILD ... LungDisease #CTILD #Diagnosis ... #Pulmonary #Rheumatology ... #Associations
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
their Disease Associations ... Polymyositis / Dermatomyositis ... Autoantibodies #Associations ... #diseases #diagnosis ... #table #rheumatology
Autoantibodies in Rheumatology • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
• Lupus (SLE): ANA ... , Others: SRP, Mi ... Polymerase Ill ... #diagnosis #associations ... #table
ANTI-MDA5 DERMATOMYOSITIS Cutaneous manifestations: • Periorbital heliotrope (blue-purple) rash with edema • Erythematous rash on the face, or the
severity of the disease ... and ILD • Liver ... frequently described Association ... #rheumatology # ... dermatology #diagnosis
Cold Urticaria Prevalence - 0.05% in the population Disease onset - Mostly 2nd to 4th decades of life Causes
clinical associations ... Disorientation, vertigo Diagnostic ... Cold #Urticaria #diagnosis ... #rheumatology # ... comparison #table
Antinuclear antibodies and Systemic lupus Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can
with disease activity ... searched for when ANA ... erythematosus #diagnosis ... #rheumatology # ... table #ANA
Inflammatory Myopathies Dermatomyositis • Onset: Subacute • Pattern: Proximal • CK: Up to 50X ULN • Autoantibodies:
Inflammatory Myopathies Dermatomyositis ... Anti-MDA5, anti-Mi ... Pattern: Proximal and ... #comparison #rheumatology ... #table
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Differential Diagnosis ... , dermatomyositis ... Non-autoimmune rheumatologic ... Erythematosus #Diagnosis ... #Rheumatology
Anti-NXP-2 Dermatomyositis What? DM with generalized subcutaneous edema Pts have more myalgias, more severe weakness, and an increased prevalence
had more severe disease ... • Myoglobin Association ... : • ILD was diagnosed ... #diagnosis #management ... #rheumatology #
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
Workup: - ANA ... Evolution: Chronic disease ... sle #comparison #table ... #rheumatology # ... diagnosis #management
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