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diagnosis autoantibodies differential hemolytic disease monoclonal oncology agglutinin aiha antibodies antinuclear autoimmune autoinflammatory behcet causes comparison e1 erythematosus extravascular gammopathies
Autoimmune Hemolytic Anemia (AIHA) - Differential Diagnosis Table Warm AIHA (48-70%) Cold AHA (16-32%) • Donath-Landsteiner HA (paroxysmal
Autoimmune Hemolytic Anemia ... Differential Diagnosis Table ... AHA (16-32%) ... Agglutinin Disease ... #hematology
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
their Disease Associations ... ANA - Non-specific ... La) - Sjogren's syndrome ... Autoantibodies #Associations ... #table #rheumatology
Autoantibodies in Rheumatology • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
Autoantibodies in Rheumatology ... • Lupus (SLE): ANA ... Autoantibodies #Rheumatology ... #diagnosis #associations ... #table
Cold Urticaria Prevalence - 0.05% in the population Disease onset - Mostly 2nd to 4th decades of life Causes
Cold Urticaria Prevalence ... clinical associations ... skin contact with cold ... Urticaria #diagnosis #rheumatology ... #comparison #table
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
) - HELLP syndrome ... (e.g. primary cold ... , Copper and lead ... differential #diagnosis #hematology ... #anemia
VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) Syndrome Clinical Syndrome: • Common Clinical Features: alveolitis, ear and
thromboembolic disease ... Abnormalities: macrocytic anemia ... criteria for 1) hematologic ... myeloid cells NEJM ... Autoinflammatory #Somatic #rheumatology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Agglutinin Syndrome ... • Symptoms of anemia ... • hemolytic anemia ... #hemolytic #anemia ... #hematology #diagnosis
Multiple Myeloma and Monoclonal Gammopathies C - HyperCalcemia- calcium > 11 mg/dL / >1 mg/dL the ULN R
ULN R - Renal disease ... 40 ml/min A - Anemia ... focal lesions on MRI ... plasmacytoma, POEMs syndrome ... MGUS #diagnosis #hematology
Antinuclear antibodies and Systemic lupus Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can
with disease activity ... searched for when ANA ... SLE-SSc-AlM overlap syndromes ... erythematosus #diagnosis #rheumatology ... #table #ANA
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
Behçet's Syndrome ... Asia • HLA-B51 association ... matter, spinal cord ... tests in Behcet syndrome ... signs #symptoms #rheumatology
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