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diagnosis differential autoantibodies comparison dermatology inflammatory myopathies myopathy aiha anemia antibodies antinuclear cold compared erythemas erythematosus gammopathies hemolytic idiopathic iims
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
their Disease Associations ... ANA - Non-specific ... common in SLE, autoimmune ... microsomal) - Autoimmune ... #table #rheumatology
Autoimmune Hemolytic Anemia (AIHA) - Differential Diagnosis Table Warm AIHA (48-70%) Cold AHA (16-32%) • Donath-Landsteiner HA (paroxysmal
Autoimmune Hemolytic ... Differential Diagnosis Table ... (48-70%) Cold AHA ... Cold Agglutinin Disease ... #hematology
Autoantibodies in Rheumatology • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
Autoantibodies in Rheumatology ... • Lupus (SLE): ANA ... Autoantibodies #Rheumatology ... #diagnosis #associations ... #table
Cold Urticaria Prevalence - 0.05% in the population Disease onset - Mostly 2nd to 4th decades of life Causes
of life Causes and ... clinical associations ... Autoimmune diseases ... Urticaria #diagnosis #rheumatology ... #comparison #table
Multiple Myeloma and Monoclonal Gammopathies C - HyperCalcemia- calcium > 11 mg/dL / >1 mg/dL the ULN R
ULN R - Renal disease ... focal lesions on MRI ... chain deposition disease ... autoimmune diseases ... MGUS #diagnosis #hematology
Antinuclear antibodies and Systemic lupus Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can
Anti-dsDNA 60-80% Association ... with disease activity ... with auto-immune diseases ... erythematosus #diagnosis #rheumatology ... #table #ANA
Inflammatory Myopathies Dermatomyositis • Onset: Subacute • Pattern: Proximal • CK: Up to 50X ULN • Autoantibodies:
Anti-MDA5, anti-Mi ... exclusion Necrotizing Autoimmune ... Pattern: Proximal and ... diagnosis #comparison #rheumatology ... #table
Erythemas Summarized Erythema ab igne • A dermatosis that results from repeated exposure to heat (fires, heating
early localized disease ... well-described associations ... Classic association ... Erythemas #comparison #table ... differential #diagnosis #dermatology
Idiopathic Inflammatory Myopathies (IIM's) RASH + MUSCLE WEAKNESS → Consider idiopathic inflammatory myopathies (IIM's) • Overlap Myositis
that occurs in association ... features of another autoimmune ... connective tissue disease ... IIMs #diagnosis #rheumatology ... #dermatology #Myopathy
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
RP-ILD), dermato-rheumatologic ... • Anti-NXP2 (ANA ... (also seen in association ... or head drop • ANA ... Myositis #Myopathy #rheumatology
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