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lupus comparison sle systemic associations differential management signs symptoms ana antinuclear antinxp2 antinxp2dm clinical dermatology dermatomyositis diseases druginduced inflammatory mimickers
Autoantibodies in Rheumatology • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
Autoantibodies in ... others (RNP, aPL antibodies ... , Others: SRP, Mi ... diagnosis #associations ... #table
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
Autoantibodies and ... Goodpasture's syndrome #Autoantibodies ... Associations #diseases #diagnosis ... #table #rheumatology ... #antibodies
Myositis Specific Antibodies (MSAs) Dermatomyositis: MDA5, TIF1y, NXP2, Mi-2, SAE Anti-Synthetase Syndrome: Jo-1, PL7, PL12, EJ, OJ Immune Mediated
Myositis Specific Antibodies ... , TIF1y, NXP2, Mi ... MSAs #clinical #diagnosis ... #rheumatology # ... table
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Systemic Lupus Erythematosus ... SLE-Related Auto-Antibodies ... Systemic #Lupus #Erythematosus ... #Diagnosis #autoantibodies ... #differential #rheumatology
Inflammatory Myopathies Dermatomyositis • Onset: Subacute • Pattern: Proximal • CK: Up to 50X ULN • Autoantibodies:
Anti-MDA5, anti-Mi ... Associated Features: Diagnosis ... #differential #diagnosis ... #comparison #rheumatology ... #table
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
• Anti-Ro/SSA autoantibodies ... Differential Diagnosis ... Non-autoimmune rheumatologic ... 1, SCL-70, RNP antibodies ... #Diagnosis #Rheumatology
Antinuclear antibodies and Systemic lupus Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can
Antinuclear antibodies ... #Antinuclear #autoantibodies ... Systemic #lupus #erythematosus ... #diagnosis #rheumatology ... #table #ANA
Features That Differentiate Acute Pericarditis from Myocardial Ischemia or Infarction and Pulmonary Embolism In contrast to the
associated with rheumatologic ... systemic lupus erythematosus ... pain, such as MI ... Presentation #comparison #Table ... #Diagnosis
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 Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
months) and of autoantibodies ... Systemic Lupus Erythematosus ... sle #comparison #table ... #rheumatology # ... diagnosis #management
Anti-NXP-2 Dermatomyositis What? DM with generalized subcutaneous edema Pts have more myalgias, more severe weakness, and an increased prevalence
without these autoantibodies ... • Antibodies targeting ... with edema • Erythematous ... Dermatomyositis #diagnosis ... #management #rheumatology
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