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management autoantibodies differential antinuclear associations comparison disease erythematosus lupus systemic workup arthritis bloodsmear borrelia classification complications criteria diseases endocarditis eularacr
Myositis Specific Antibodies (MSAs) Dermatomyositis: MDA5, TIF1y, NXP2, Mi-2, SAE Anti-Synthetase Syndrome: Jo-1, PL7, PL12, EJ, OJ Immune Mediated
Myositis Specific ... , TIF1y, NXP2, Mi ... #clinical #diagnosis ... #rheumatology # ... table
Autoantibodies in Rheumatology • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
• Lupus (SLE): ANA ... others (RNP, aPL antibodies ... , Others: SRP, Mi ... #diagnosis #associations ... #table
Inflammatory Myopathies Dermatomyositis • Onset: Subacute • Pattern: Proximal • CK: Up to 50X ULN • Autoantibodies:
Inflammatory Myopathies ... Anti-MDA5, anti-Mi ... Pattern: Proximal and ... #comparison #rheumatology ... #table
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
Disease Associations ANA ... - Non-specific; ... Associations #diseases #diagnosis ... #table #rheumatology ... #antibodies
Antinuclear antibodies and Systemic lupus Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can
Antinuclear antibodies ... -15% If SLE is clinically ... erythematosus #diagnosis ... #rheumatology # ... table #ANA
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antinuclear Antibodies ... Antibody refers to antibodies ... likely it will be clinically ... but often not specific ... #rheumatology #diagnosis
IgG4-Related Disease Clinical history: Man, 60 years, multiorgan involvement, unique or multiple inflammatory pseudotumor 4 phenotypes: •
Related Disease Clinical ... relapse No specific ... autoantibodies (antinuclear antibodies ... Histology - Non-specific ... workup #treatment #rheumatology
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus Clinical Domains: • Constitutional domain: Fever • Cutaneous domain: Non-scarring
Erythematosus Clinical ... C4 • Highly specific ... antibodies domain ... Erythematosus #diagnosis ... #rheumatology
Differentiating NBTE from Infective Endocarditis No pathognomonic signs/symptoms or echo features that are specific to NBTE, and
features that are specific ... to NBTE, and diagnosis ... heart valves • MRI ... often seen • MRI ... #table
Transverse Myelitis Overview Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
Transverse Myelitis - Clinical ... bouts of HTN Diagnostic ... Transverse Myelitis Diagnosis ... out compressive myelopathies ... Antiamphiphysin antibodies
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