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management differential comparison lupus treatment erythematosus sle antinuclear autoantibodies cardiology cardiomyopathy disease infectiousdiseases myopathy myositis neurology signs symptoms workup algorithm
Autoantibodies in Rheumatology • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
• Lupus (SLE): ANA ... others (RNP, aPL antibodies ... • Scleroderma (Systemic ... #diagnosis #associations ... #table
Myositis Specific Antibodies (MSAs) Dermatomyositis: MDA5, TIF1y, NXP2, Mi-2, SAE Anti-Synthetase Syndrome: Jo-1, PL7, PL12, EJ, OJ Immune Mediated
Myositis Specific Antibodies ... , TIF1y, NXP2, Mi ... #MSAs #clinical ... #diagnosis #rheumatology ... #table
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antinuclear Antibodies ... Antibody refers to antibodies ... likely it will be clinically ... #Antinuclear #Antibodies ... #rheumatology #diagnosis
Inflammatory Myopathies Dermatomyositis • Onset: Subacute • Pattern: Proximal • CK: Up to 50X ULN • Autoantibodies:
Inflammatory Myopathies ... Anti-MDA5, anti-Mi ... Pattern: Proximal and ... #comparison #rheumatology ... #table
Restrictive Cardiomyopathy - Diagnosis and Causes Clinical: Dyspnea, Exercise Intolerance, ↑ "Right Sided-Symptoms" (ascites, hepatomegaly, ↑↑peripheral edema) Physical
Cardiomyopathy - Diagnosis ... and Causes Clinical ... Echocardiography, Cardiac MRI ... Cardiomyopathy, Systemic ... , Myofibrillar Myopathies
Antinuclear antibodies and Systemic lupus Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can
Antinuclear antibodies ... and Systemic lupus ... -15% If SLE is clinically ... #rheumatology # ... table #ANA
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus Clinical Domains: • Constitutional domain: Fever • Cutaneous domain: Non-scarring
Erythematosus Clinical ... low C4, Low C3 and ... Highly specific antibodies ... Erythematosus #diagnosis ... #rheumatology
Differentiating NBTE from Infective Endocarditis No pathognomonic signs/symptoms or echo features that are specific to NBTE, and
features: Fever -, Systemic ... heart valves • MRI ... features: Fever +, Systemic ... often seen • MRI ... #table
IgG4-Related Disease Clinical history: Man, 60 years, multiorgan involvement, unique or multiple inflammatory pseudotumor 4 phenotypes: •
Related Disease Clinical ... female, asian • Systemic ... PET-CT Imaging (→ Diagnostic ... autoantibodies (antinuclear antibodies ... workup #treatment #rheumatology
Statin Induced Muscle Toxicity - Summary Clinical Presentation: • Elevations of serum creatine kinase with proximal myalgia
Toxicity - Summary Clinical ... syndrome (GBS), systemic ... → Inflammatory myopathies ... myopathy (IMNM) → Antibodies ... IU/I • SAMS clinical
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