13 results
Causes of Hypercalcemia
Hypercalcemia due to increased bone Ca2+ resorption:
 • Primary hyperparathyroidism, Malignancy, Pseudohyperparathyroidism, Renal failure,
Causes of Hypercalcemia ... )-alkali syndrome ... #Causes #differential ... #diagnosis #calcium ... #high #endocrinology
Causes of Hypercalcemia
Parathyroid hormone–dependent
Primary hyperparathyroidism
Familial hypocalciuric hypercalcemia
Lithium-associated
Tertiary hyperparathyroidism
Genetic disorders (e.g., multiple endocrine neoplasia type 1 or
Causes of Hypercalcemia ... hypocalciuric hypercalcemia ... hyperparathyroidism Genetic ... #Causes #Differential ... #Diagnosis #Endocrinology
Causes of Hypercalcemia due to increased Vitamin D levels
 • The BIG 3:
Causes of Hypercalcemia ... Paraffin-associated granuloma • Genetic ... : Williams syndrome ... #VitaminD #causes ... differential #diagnosis #endocrinology
Treatment algorithm for malignancy-associated hypercalcemia.
Hypercalcemia
 - Renal Failure → Dialysis with low Ca++ bath
Aggressive IV hydration
Hypercalcemia - ... Bisphosphonate +/- Calcitonin ... Refractory Cases ... : Gallium nitrate ... algorithm #management #endocrinology
Causes of Hypercalcemia
Parathyroid gland structure-related
 • Primary hyperparathyroidism
 • Parathyroid adenoma
 • Parathyroid hyperplasia
 • Parathyroid
Causes of Hypercalcemia ... Lithium use • Calcium-sensing ... • Milk-alkali syndrome ... #Hypercalcemia ... #Causes #endocrinology
21-Hydroxylase Deficiency (21-OHD): Pathogenesis and Clinical Findings
Autosomal recessive mutation in CYP21A2 coding for the enzyme 21-OHase
enzyme 21-OHase causes ... wasting crisis & hyperkalemia ... Hirsutism & acne • Infertility ... #21HydroxylaseDeficiency #21OHD #pathophysiology ... #genetics #endocrinology
Causes of Hypocalcemia by Clinical Cause

Acute illness: pancreatitis, tumor lysis, severe illness - Secondary hyperparathyroidism from
Causes of Hypocalcemia ... - Genetic defects ... in calcium-sensing ... Malabsorption syndrome ... #Diagnosis #Endocrinology
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
vs Tumor Lysis Syndrome ... Leukostasis: • Pathophysiology ... high WBC count cause ... : • Pathophysiology ... hydration - Hyperkalemia
Sarcoidosis - Diagnosis and Management Summary
Epidemiology
1) High incidence in Scandinavian countries (11-24 cases per 100,000 individuals
survival is 93-95% Pathophysiology ... fibrosis. 4) Calcium ... hyperphosphatemia, hypercalcemia ... symptoms are not caused ... patients) and/or hypercalcuria
Causes of Hypocalcemia - Differential Diagnosis
Decreased calcium absorption
 • Vitamin D deficiency
    -
Causes of Hypocalcemia ... Diagnosis Decreased calcium ... Malabsorption Syndromes ... Hypoparathyroidism - Genetic ... #endocrinology