43 results
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Manifestations of Systemic Lupus ... autoantibodies that will cause ... Puncture, EEG Treatment ... CNS #neurology #rheumatology ... diagnosis #management #treatment
Management of Lupus Nephritis
Lupus nephritis (LN) in 10 to 40% of SLE
Hallmark = proteinuria 20.5 g/g
Nephritis Lupus ... severity (ISN/RPS classification ... by 12 months Classification ... Nephritis #Management #treatment ... #management #rheumatology
Causes of Isolated Neutropenia - Differential Diagnosis Algorithm
Congenital
Medications
 • Anticonvulsants
 • Antibiotics
 • Antithyroid
 • Antihypertensive
Causes of Isolated ... Algorithm Congenital Medications ... Destruction • Systemic Lupus ... Diagnosis #Algorithm #Causes ... #Hematology
Interstitial Lung Diseases (ILD)
Exposure-Related ILD (a.k.a. extrinsic allergic alveolitis): 
 • Hypersensitivity pneumonitis, Farmer's lung, Bird
ILD caused by inhalation ... pneumonitis • Medication-induced ... Polymyositis-dermatomyositis, Lupus ... • Idiopathic pulmonary ... #causes
Hydroxychloroquine Serum Measurement in SLE
 • Terminal elimination half-life = 40 days ([HCQI reflects long-term intake)
200ng/mL Best indications ... suspected) • In case ... • Special cases ... Measurement #SLE #rheumatology ... pharmacology #levels #lupus
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary
 • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... , oral ulcers, Lupus ... Positive in 60-80% of cases ... life-threatening • Treatment ... Management #Summary #rheumatology
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
cases, drug-dependent ... constitutional symptoms • Treatment ... Discontinuation of causal ... life-threatening • Treatment ... comparison #table #rheumatology
Causes of Pleural Effusion - Differential Diagnosis Algorithm
Transudate - Hydrostatic
 • Congestive heart failure
 • Constrictive
Causes of Pleural ... Malignancy • Pulmonary ... Post-CABG • Medication ... Pleural #Effusion #Pulmonary ... #causes
Clinical Classification of Pulmonary Hypertension

1. Pulmonary arterial hypertension from pulmonary vasculopathy
Idiopathic pulmonary arterial hypertension
Heritable gene mutations
Clinical Classification ... Pulmonary arterial ... multifactorial mechanisms Hematologic ... Hypertension #PHTN #Classification ... #Differential #Causes
Rapidly Progressive Glomerulonephritis (RPGN)
RPGN has three primary pathophysiologic causes differentiated by immunofluorescence

Immune Complex Mediated (granular staining):
pathophysiologic causes ... Post-strep GN, Lupus ... With associated pulmonary ... diagnosis #algorithm #rheumatology