235 results
Hypernatremia Differential Diagnosis Algorithm - Diabetes Insipidus Workup

Step #1 - Consider the history
Step #2 - Assess
Algorithm - Diabetes Insipidus ... Management #Algorithm #Sodium ... #nephrology #insipidus
Causes of Hypernatremia - Differential Diagnosis
Inadequate water intake:
 • Lack of access to water
Extrarenal hypotonic fluid
Central diabetes insipidus ... Nephrogenic diabetes insipidus ... Causes #nephrology #sodium
Etiologies of Hypernatremia - Differential Diagnosis
GI losses / Insensible losses
Sodium Overload
Transcellular Movement of Water
Central Diabetes Insipidus
Insensible losses Sodium ... Central Diabetes Insipidus ... Nephrogenic Diabetes Insipidus
Diabetes Insipidus - Diagnosis Algorithm
Tests:
 • Osmolality, Urine AND/OR
 • Osmolality, Serum or Plasma AND
 •
Diabetes Insipidus ... Plasma AND • Sodium ... ARUPLabs #Diabetes #Insipidus
Causes of Hypernatremia - Differential Diagnosis Algorithm
Hypernatremia - Excess free water loss, Serum Sodium >145 mmol/L
High
water loss, Serum Sodium ... kg • Diabetes Insipidus
Inherited Defects in Kidney Tubule Epithelial Cells

Renal glucosuria - Na+-dependent glucose cotransporter
Cystinuria - Amino acid transporter
Bartter
cell epithelial sodium ... of epithelial sodium ... Nephrogenic diabetes insipidus
Hypernatremia - Differential Diagnosis Workup Algorithm

1) Check Urine Osmolality:
 > 600 mOsm/kg - Implies extrarenal mechanism
Euvolemic: Diabetes insipidus ... Algorithm #nephrology #sodium
Primary Polydipsia
Definition: Excessive volitional water intake
Epidemiology:
 • 6-20% of patients with psychiatric disorders - Most commonly
Co-morbid diabetes insipidus ... Diagnosis: Diabetes Insipidus ... Urine Osm, Serum Sodium ... , Urine Sodium
Hypernatremia - Differential Diagnosis and Treatment
Hypernatremia is almost always due to unreplaced water loss (free water
post-obstructive 3) Diabetes Insipidus ... management #nephrology #sodium
Diabetes Insipidus vs Syndrome of Inappropriate ADH (SIADH) - Comparison Table

Diabetes Insipidus - Inadequate ADH
SIADH -
Diabetes Insipidus ... Table Diabetes Insipidus ... #Diabetes #Insipidus