10 results
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
) Pathophysiology ... accumulation of clinical ... Assessment • Clinical ... of emergency, ICU ... #management #treatment
Hemophagocytic Lymphohistiocytosis (HLH)
Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
: Overwhelming clinical ... : HLH signs and ... presents as an acute ... • Bicytopenia Treatment ... #management #treatment
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Triggers: ATRA treatment ... Pathophysiology ... common • Imaging: CXR ... organ dysfuxtion, ICU ... • Supportive Care
Cullen's sign. Lipase 1,781. Bruising in the skin around the umbilicus. This sign is named after
associated with acute ... Pathophysiology: ... : While it's a rare ... is not diagnostic ... peritonitis #IM #FM #ICU
It is important to recognize Acute Decompensated Heart Failure (ADHF) as more than just simply a
important to recognize Acute ... Signs of poor perfusion ... Signs of congestion ... Cardiac cath if acute ... #criticalcare #icu
Hemophagocytic Lymphohistiocytosis (HLH)

High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
HLH is a critical ... are essential ... Clinical Presentation ... • Common Signs ... Pathophysiology
Guillain-Barré Syndrome (GBS)
Acute autoimmune demyelinating polyradiculoneuropathy that presents with rapidly progressive flaccid weakness
Epidemiology:
 • Incidence: 1
Syndrome (GBS) Acute ... the underlying pathophysiology ... and cauda equina TREATMENT ... the intensive care ... unit (ICU) and
Sarcoidosis - Diagnosis and Management Summary
Epidemiology
1) High incidence in Scandinavian countries (11-24 cases per 100,000 individuals
Sarcoidosis - Diagnosis ... survival is 93-95% Pathophysiology ... renal failure Clinical ... e.g. incidental CXR ... #Management #Signs
Cryptogenic Organizing Pneumonia - Illness Script

PATHOPHYSIOLOGY: Unknown trigger, reversible inflammatory/fibroproliferative process. Polypoid fibroblastic aggregates that plug
Illness Script PATHOPHYSIOLOGY ... Males=Females SIGNS ... /SYMPTOMS: • Acute ... : Clinical diagnosis ... , neoplastic) TREATMENT
Conduct Disorder (CD): Pathogenesis and clinical findings
 - Must have >3 symptoms present in the past
Pathogenesis and clinical ... house, building or car ... BehavioralDisorder #Pathophysiology ... #diagnosis #symptoms ... #signs #psychiatry