23 results
Approach to Elevated aPTT / PT - Differential Diagnosis Algorithm

aPTT: Intrinsic / Final
PT: Extrinsic / Final

By
/ PT - Differential ... Diagnosis Algorithm ... aPTT: Intrinsic ... #Hematology #differential ... #diagnosis
Causes of Prolonged PT (INR), Prolonged PTT
 • Prolonged PT (INR), Prolonged PTT
 • Prolonged PT
Causes of Prolonged PT ... • Prolonged PT ... #INR #Differential ... #Diagnosis #Algorithm ... #Causes #Hematology
Approach to Thrombotic Microangiopathy (TMA) - Differential Diagnosis and Management Algorithm

Suspected TMA: Unexplained thrombocytopenia + MAHA
Diagnosis and Management ... /aPTT MAHA likely ... hemosiderin • PT ... /aPTT normal • ... #Algorithm #hematology
Differential Diagnosis for a Prolonged PT and aPTT
If the PT and the aPTT are both prolonged,
Differential Diagnosis ... PT and the aPTT ... #Causes #diagnosis ... #differential # ... hematology #coagulation
Pancytopenia - Differential Diagnosis Algorithm
 • 12-13 g/dL,
 • ANC < 1800/uL,
 • platelet < 150,000/uL

Initial
Diagnosis Algorithm ... iron studies, PT ... /aPTT Differential ... Diagnosis: • ... #hematology #workup
Von Willebrand Disease - Most common inherited bleeding disorder 
Clinical 
 • Easy bruising 
 •
2B) • Normal PT ... INR • Normal aPTT ... factor VIII) Treatment ... VonWillebrand #Disease #Diagnosis ... #Hematology
Causes of Abnormal PT and/or aPTT
Prolonged Prothrombin Time (PT)
1. Acquired deficiency of FVII
(exceptionally rare ... common pathways (rare ... #Causes #diagnosis ... #differential # ... hematology #coagulation
Hemophilia - Diagnosis and Management
Diagnosis:
 • Consistent bleeding history (unless screening for disease in family members
established disease) • aPTT ... mixing study (aPTT ... mild cases) • PT ... multidisciplinary care ... #hematology
Thrombotic Microangiopathy - TTP VS HUS

Big picture points : Often hard to differentiate the two entities,
Often hard to differentiate ... distinction has HUGE treatment ... and first-line treatment ... thrombocytopenia #Comparison #Diagnosis ... #Table #Hematology
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
• Prolonged PT ... Fibrinogen: ↓ • PT ... INR < 2.3 - APTT ... #Coagulation #diagnosis ... #management #hematology