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management differential hematology treatment oncology algorithm clinical arthritis causes neurology orthopedics symptoms anemia gout injury joint leukemia pain pathophysiology radiology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
, CLL Acute leukemias ... ALL (Acute Lymphoblastic ... develop leukostasis syndrome ... • Tumor lysis syndrome ... #Oncology #Diagnosis
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
large numbers and are ... Physical Exam/Signs ... Diagnosis: • ... • Richter’s Syndrome ... ’s lymphoma or acute
Acute Spinal Cord Injuries: Pathogenesis and clinical findings • Anterior Cord Syndrome -> Anterior spinal artery
Acute Spinal Cord ... -> Trauma, disc ... #diagnosis #pathophysiology ... #signs #symptoms ... #msk #orthopedics
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic Syndrome ... transformation to acute ... Conservative/supportive care ... Allogeneic stem cell ... Myelodysplastic #Syndrome
Vascular Joint Pain - Differential Diagnosis Algorithm - Constant Pain (Ischemia) - Acute Onset -
- Differential Diagnosis ... (Ischemia) - Acute ... Occlusion • Sickle Cell ... Marfan's Syndrome ... Vascular #JointPain #MSK
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... • Mechanical Trauma ... ) - HELLP syndrome ... ) (e.g. lupus, CLL ... #hematology #anemia
Aplastic Anemia - Illness Script Signs and symptoms: • Recurrent infections from neutropenia • Mucosal bleeding from
Illness Script Signs ... Symptomatic anemia Diagnosis ... Consider stem cell ... • Supportive care ... progress to MDS or acute
Gout (Gouty Arthritis) - MSK Radiology Imaging Findings: • Eccentric soft-tissue densities surrounding the third proximal interphalangeal
Gouty Arthritis) - MSK ... mass and NO prior signs ... - **MSK rads ... • PVNS/Giant Cell ... #msk #rheumatology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... • Induce blast cell ... • Supportive Care ... Differentiation #Syndrome ... #management #hematology
Sarcoidosis - Diagnosis and Management Summary Epidemiology 1) High incidence in Scandinavian countries (11-24 cases per 100,000 individuals
Sarcoidosis - Diagnosis ... and progressive Acute ... anterior/posterior MSK ... : ACUTE, fever, ... #Management #Signs
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